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A Rat Orthotopic Renal Transplantation Model for Renal Allograft Rejection
Published on: February 2, 2022
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ABO incompatibility in renal transplantation
Mahmoud Mohamed1, Tara Sweeney2, Duaa Alkhader3
1Department of Medicine, North Mississippi Medical Center, Tupelo, MS 38804, United States.
World Journal of Transplantation
|October 11, 2021
Summary
ABO blood group incompatible kidney transplants are now feasible, overcoming historical barriers. Advances in immunosuppression allow successful transplantation, reducing waitlist times.
Area of Science:
- Nephrology
- Immunology
- Transplantation
Background:
- ABO blood group incompatibility (ABO-I) traditionally precluded kidney transplantation due to high rejection risk.
- A significant gap exists between kidney transplant candidates and available donors.
- Potent immunosuppression therapies are advancing transplantation possibilities.
Purpose of the Study:
- To review ABO-I kidney transplantation.
- To discuss protocols for overcoming ABO-I barriers.
Main Methods:
- Literature review of ABO-I kidney transplantation protocols.
- Analysis of immunosuppression strategies.
Main Results:
- ABO-I kidney transplantation is increasingly viable.
- Specific protocols enable successful transplants despite incompatibility.
- Improved immunosuppression mitigates rejection risks.
Conclusions:
- ABO-I kidney transplantation is a viable option to expand donor pool.
- Careful protocol selection is crucial for successful outcomes.
- This approach addresses donor shortages in kidney transplantation.
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