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Human Three-Dimensional Hepatic Models: Cell Type Variety and Corresponding Applications.

Qianqian Xu1

  • 1School of Chinese Medicine, and Centre for Cancer and Inflammation Research, Hong Kong Baptist University, Hong Kong, China.

Frontiers in Bioengineering and Biotechnology
|October 11, 2021
PubMed
Summary

Human 3D hepatic models using diverse cell types improve drug development and disease modeling. This review details cell types and their applications in 3D liver models for research and transplantation.

Keywords:
drug developmenthepatic cell typeshepatocyte transplantationin vitro 3D modelliver disease

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Area of Science:

  • Hepatology and Regenerative Medicine
  • Biotechnology and Drug Development

Background:

  • Conventional 2D cell cultures and species-specific drug metabolism present limitations in drug development and disease modeling.
  • Human 3D hepatic models offer retained hepatic phenotypes and functions, addressing these limitations.

Purpose of the Study:

  • To review the characteristics of different hepatic cell types used in 3D models.
  • To discuss the applications of these cell types in drug development, liver disease modeling, and liver transplantation.

Main Methods:

  • Comprehensive literature review of studies utilizing diverse hepatic cell types in 3D models.
  • Analysis of cell type characteristics, including primary human hepatocytes, hepatic cancer cell lines, and stem cell-derived hepatocyte-like cells.

Main Results:

  • Primary human hepatocytes mimic in vivo profiles, ideal for hepatotoxicity studies.
  • Hepatic cancer cell lines offer reproducibility, while stem cell-derived cells support personalized and regenerative medicine.
  • Each cell type possesses unique advantages for specific in vitro 3D modeling applications.

Conclusions:

  • Understanding hepatic cell type variety is crucial for optimizing 3D hepatic models.
  • Diverse cell types in 3D models present significant opportunities for advancing drug development, disease modeling, and liver transplantation research.