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Plasma Heat Shock Protein 70 Is Associated With the Onset of Acute Myocardial Infarction and Total Occlusion in
Runda Wu1,2, Wei Gao1,2, Zheng Dong1,2
1Department of Cardiology, Zhongshan Hospital, Fudan University, Shanghai, China.
Insights
Plasma heat shock protein 70 (HSP70) levels are lower in acute myocardial infarction (AMI) patients compared to chronic coronary syndrome (CCS) patients. HSP70 shows moderate predictive value for AMI and STEMI, but slight predictive value for total occlusion.
Area of Science:
- Cardiovascular Medicine
- Biomarkers
- Molecular Biology
Background:
- The role of plasma heat shock protein 70 (HSP70) in acute myocardial infarction (AMI) is debated.
- The relationship between HSP70 and total coronary artery occlusion is not well understood.
- Investigating HSP70 as a potential biomarker in cardiovascular diseases is crucial.
Purpose of the Study:
- To investigate the diagnostic and predictive value of plasma HSP70 in patients with AMI.
- To compare plasma HSP70 levels between AMI and chronic coronary syndrome (CCS) patients.
- To assess the correlation of HSP70 with clinical outcomes and cardiac function.
Main Methods:
- Plasma HSP70 levels were measured using ELISA in 112 AMI patients and 52 CCS patients.
- Measurements were taken on day 1 and day 7 post-AMI, and before angiography in CCS patients.
- Biomarkers including NT-proBNP, CRP, cTnT, and left ventricular ejection fraction (LVEF) were analyzed.
Main Results:
- Plasma HSP70 was significantly higher in CCS patients than in AMI patients (P < 0.0001).
- HSP70 levels decreased significantly from day 1 to day 7 after AMI (P < 0.01).
- Elevated HSP70 correlated with lower LDL-C, peak cTnT, NT-proBNP, CRP, and diagnosis of AMI/STEMI, but higher diagnosis of total occlusion.
Conclusions:
- Plasma HSP70 levels are lower in AMI patients compared to CCS patients and decrease post-AMI.
- HSP70 demonstrates moderate predictive value for AMI and STEMI, and slight predictive value for total coronary occlusion.
- HSP70 is negatively associated with in-hospital stay and positively correlated with LVEF at 1-year follow-up.
Abstract:
Background: Whether the role of plasma heat shock protein 70 (HSP70) in acute myocardial infarction (AMI) is protective or detrimental remains debated, and the relationship between HSP70 and total occlusion remains elusive. Methods: A total of 112 patients with primary diagnosis of AMI and 52 patients with chronic coronary syndrome (CCS) were enrolled into the study. Plasma HSP70 level was determined by ELISA on day 1 and day 7 after the onset of AMI and was examined before angiography in patients with CCS. Peak NT-proBNP, high-sensitivity C-reactive protein (CRP), troponin T (cTnT), and left ventricular ejection fraction were measured. Results: Plasma HSP70 was significantly higher in CCS than AMI (P < 0.0001), and it showed a significant decrease from day 1 to day 7 after AMI (P < 0.01). Elevated HSP70 was associated with decreased levels of LDL-C (P < 0.05), peak cTnT (R = -0.3578, P < 0.0001), peak NT-proBNP (R = -0.3583, P < 0.0001), and peak CRP (R = -0.3539, P < 0.0001) and a lower diagnosis of AMI (R = -0.4016, P < 0.0001) and STEMI (R = -0.3675, P < 0.0001), but a higher diagnosis of total occlusion in target vessels (R = 0.1702, P < 0.05). HSP70 may provide certain predictive value for the diagnosis of AMI, STEMI, and total occlusion in target vessels, and the area under the receiver operating characteristic curves were 0.7660, 0.7152, and 0.5984, respectively. HSP70 was also negatively associated with in-hospital stay (P < 0.001) and positively correlated with left ventricular ejection fraction (LVEF) at 1-year follow-up (P < 0.05), despite no association with in-hospital major adverse cardiovascular events (MACE). Conclusion: Plasma HSP70 level was found to decrease from day 1 to day 7 post-AMI, but the overall level of patients with AMI was lower than that of patients with CCS. However, the ability of HSP70 to identify clinically significant AMI and STEMI was moderate, and the predictive value to total occlusion was slight.
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