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Updated: Aug 18, 2026

Assessment of Morphine-induced Hyperalgesia and Analgesic Tolerance in Mice Using Thermal and Mechanical Nociceptive Modalities
Published on: July 29, 2014
Algesimetry--a necessity in research on analgesic drugs
Abstract:
In addition to the methods of clinical algesimetry, the investigation of the actions of analgesic drugs requires reliable and sensitive methods of experimental algesimetry. In contrast to the clinical investigation of analgesic actions, the methodology of the experimental testing of analgesics in humans is still rudimentary. The difficulties encountered in experimental algesimetry are discussed in this contribution, and an algesimetric study is presented illustrating experimental methods with which the pharmacodynamics of peripherally acting analgesics may be investigated.
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