Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Assessment of Diffusion and Perfusion01:17

Assessment of Diffusion and Perfusion

1.2K
Understanding and evaluating diffusion and perfusion is critical in assessing a patient's respiratory and circulatory health. These processes play key roles in maintaining the body's internal environment, ensuring that tissues receive adequate oxygen while waste products are efficiently removed.
The Role of Diffusion in Respiration
Diffusion is the process by which molecules move from an area of higher concentration to an area of lower concentration. In the respiratory system, this...
1.2K
Diffusion01:21

Diffusion

5.6K
Diffusion is a type of passive transport. In passive transport, a substance tends to move from an area of high concentration to an area of low concentration until the concentration is equal across the space. For example, take the diffusion of substances through the air. When someone opens a perfume bottle in a room filled with people, the perfume is at its highest concentration in the bottle and is at its lowest at the edges of the room. The perfume vapor will diffuse, or spread away, from the...
5.6K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Normative T<sub>1</sub> and T<sub>2</sub> Brain Atlases Across the Adult Lifespan in a Chinese Cohort: Multicenter Quantitative MRI Benchmarks for Ageing and Neurodegenerative Research.

Human brain mapping·2026
Same author

When little brain goes to school: Impact of pedagogy on cerebellar peduncles' development.

Developmental cognitive neuroscience·2026
Same author

Introducing a translationally relevant mouse model of radiosurgery-induced unilateral hearing loss.

Frontiers in neuroscience·2026
Same author

How Much Does Motion Matter? Evaluating the Motion Robustness of pTx Pulses at 7 T.

Magnetic resonance in medicine·2026
Same author

Combined caLculation of Ultra-high field Biases (CLUB) With Sandwich: Fast, Simultaneous Estimation of 3D B<sub>0</sub> and Multi-Channel B<sub>1</sub> <sup>+</sup> Maps at 7 T.

Magnetic resonance in medicine·2026
Same author

CATERPillar: a flexible framework for generating white matter numerical substrates with incorporated glial cells.

Medical image analysis·2026
Same journal

Dataset of pesticide and trace metal concentrations in the pollen provisions of wild bees and surrounding soils across European bee hotels.

Data in brief·2026
Same journal

Dataset of structure-activity relationships in Pd/ZrO<sub>2</sub>-TiO<sub>2</sub> catalysts for furfural reductive amination: Batch vs Operando ATR-FTIR.

Data in brief·2026
Same journal

Dine in or take out dataset: user behavior in an interactive virtual reality café.

Data in brief·2026
Same journal

Heavy commercial vehicles' disposition: Anonymized dataset of German truck freight transport order trips (DT-DISPO).

Data in brief·2026
Same journal

A harmonized fast-fashion garment-variant dataset for textile circularity and sustainability assessment.

Data in brief·2026
Same journal

Terahertz reflectivity dataset: Reading text on both sides of the page.

Data in brief·2026
See all related articles

Related Experiment Video

Updated: Oct 17, 2025

Measuring Connectivity in the Primary Visual Pathway in Human Albinism Using Diffusion Tensor Imaging and Tractography
13:26

Measuring Connectivity in the Primary Visual Pathway in Human Albinism Using Diffusion Tensor Imaging and Tractography

Published on: August 11, 2016

12.4K

The diffusion-simulated connectivity (DiSCo) dataset.

Jonathan Rafael-Patino1, Gabriel Girard1,2,3, Raphaël Truffet4

  • 1Signal Processing Lab (LTS5), École Polytechnique Fédérale de Lausanne, Switzerland.

Data in Brief
|October 11, 2021
PubMed
Summary
This summary is machine-generated.

Researchers developed a novel numerical phantom for validating brain connectome mapping using diffusion-weighted MRI. This tool enhances the reliability of structural connectome estimation and its microstructural accuracy.

Keywords:
Diffusion MRIMicrostructureMonte CarloNumerical phantomSimulationStructural connectivityTractography

More Related Videos

Cerebral Blood Flow-Based Resting State Functional Connectivity of the Human Brain using Optical Diffuse Correlation Spectroscopy
07:13

Cerebral Blood Flow-Based Resting State Functional Connectivity of the Human Brain using Optical Diffuse Correlation Spectroscopy

Published on: May 27, 2020

6.7K
Dynamic Inter-subject Functional Connectivity Reveals Moment-to-Moment Brain Network Configurations Driven by Continuous or Communication Paradigms
08:36

Dynamic Inter-subject Functional Connectivity Reveals Moment-to-Moment Brain Network Configurations Driven by Continuous or Communication Paradigms

Published on: March 21, 2019

7.4K

Related Experiment Videos

Last Updated: Oct 17, 2025

Measuring Connectivity in the Primary Visual Pathway in Human Albinism Using Diffusion Tensor Imaging and Tractography
13:26

Measuring Connectivity in the Primary Visual Pathway in Human Albinism Using Diffusion Tensor Imaging and Tractography

Published on: August 11, 2016

12.4K
Cerebral Blood Flow-Based Resting State Functional Connectivity of the Human Brain using Optical Diffuse Correlation Spectroscopy
07:13

Cerebral Blood Flow-Based Resting State Functional Connectivity of the Human Brain using Optical Diffuse Correlation Spectroscopy

Published on: May 27, 2020

6.7K
Dynamic Inter-subject Functional Connectivity Reveals Moment-to-Moment Brain Network Configurations Driven by Continuous or Communication Paradigms
08:36

Dynamic Inter-subject Functional Connectivity Reveals Moment-to-Moment Brain Network Configurations Driven by Continuous or Communication Paradigms

Published on: March 21, 2019

7.4K

Area of Science:

  • Neuroimaging
  • Computational Neuroscience
  • Biophysics

Background:

  • Mapping the brain's structural connectome using diffusion-weighted magnetic resonance imaging (DW-MRI) is crucial for understanding brain anatomy and function.
  • Accurate estimation of the structural connectome relies on robust white matter tractography methods and detailed microstructural information.
  • A lack of suitable numerical phantoms has previously hindered the validation of these tractography methods and microstructural assessments.

Purpose of the Study:

  • To develop a novel, high-resolution numerical phantom that accurately mimics complex white matter tract trajectories and microstructural features.
  • To enable comprehensive validation of quantitative tractography methods used in structural connectome estimation.
  • To assess the reliability of connectome estimation and its adherence to nervous tissue microstructure.

Main Methods:

  • Creation of a 1 mm³ numerical phantom with micrometric resolution, simulating 12,196 synthetic tubular fibers (1.4–4.2 µm diameter) interconnecting 16 regions of interest.
  • Incorporation of microstructural features including axonal diameter distribution, myelin presence, and packing densities.
  • Generation of DW-MRI images via Monte Carlo simulations of spin dynamics to capture tissue properties (e.g., fibre diameter, diffusion, free water) and macroscopic anatomical resemblance.

Main Results:

  • The developed phantom successfully mimics complex anatomical fiber pathways and key microstructural properties of nervous tissue.
  • Simulated DW-MRI images possess both microscopic realism (fiber diameter, diffusion characteristics) and macroscopic anatomical fidelity (smooth trajectories).
  • This phantom integrates validation for both tractography accuracy and microstructural adherence, addressing limitations of previous phantoms.

Conclusions:

  • The novel numerical phantom provides an unprecedented tool for validating structural connectome estimation from DW-MRI data.
  • It facilitates a more rigorous assessment of tractography reliability and its correlation with biological microstructure.
  • This advancement is expected to significantly improve the accuracy and trustworthiness of brain connectome mapping in neuroscience research.