Multiplex Biosensing for Simultaneous Detection of Mutations in SARS-CoV-2

Area of Science:

• Virology
• Biotechnology
• Public Health

Background:

• The COVID-19 pandemic, caused by SARS-CoV-2, is a major global health crisis.
• Emergence of highly transmissible SARS-CoV-2 variants like Alpha, Beta, and Delta necessitates advanced detection methods.
• Current diagnostic tools face challenges in rapidly identifying multiple mutations simultaneously.

Purpose of the Study:

• To address the urgent need for efficient SARS-CoV-2 genotyping.
• To highlight the importance of developing integrated multiple biosensor systems.
• To enable rapid, simultaneous detection of current and future SARS-CoV-2 mutations.

Main Methods:

• Review of biosensor applications in SARS-CoV-2 detection.
• Exploration of integrated multiple biosensor technologies.
• Discussion of novel biosensor combinations with other technologies.

Main Results:

• Biosensors are crucial tools for SARS-CoV-2 detection and pandemic control.
• Integrated multiple biosensor systems can achieve rapid, simultaneous detection of multiple SARS-CoV-2 mutations.
• Novel biosensor approaches offer reliable and effective detection of SARS-CoV-2 variants.

Conclusions:

• Developing advanced biosensor systems is critical for managing the COVID-19 pandemic.
• Simultaneous detection of SARS-CoV-2 mutations is essential for effective public health strategies.
• Future pandemic preparedness relies on innovative biosensing technologies for variant surveillance.