Related Experiment Video

Updated: Oct 17, 2025

Real-Time Monitoring of Neurocritical Patients with Diffuse Optical Spectroscopies
07:12

Real-Time Monitoring of Neurocritical Patients with Diffuse Optical Spectroscopies

Published on: November 19, 2020

2.3K

Outcomes and Spectrum of Major Neurovascular Events Among COVID-19 Patients: A 3-Center Experience

Blake E S Taylor1, Priyank Khandelwal1, Michael S Rallo2

  • 1Department of Neurosurgery, Rutgers New Jersey Medical School, Newark, New Jersey.

Neurosurgery Open
|October 11, 2021
PubMed

Insights

Coronavirus Disease-2019 (COVID-19) is linked to severe cerebrovascular events, including large-vessel occlusions (LVOs), with high mortality. Lower D-dimer and better admission neurological status may predict better outcomes in COVID-19 patients with stroke.

Area of Science:

  • Neurology
  • Infectious Diseases
  • Vascular Medicine

Background:

  • Preliminary data suggest Coronavirus Disease-2019 (COVID-19) is associated with hypercoagulability and neurovascular events.
  • Limited data exists on the outcomes of COVID-19 patients experiencing cerebrovascular events.

Purpose of the Study:

  • To report the clinical course and outcomes of COVID-19 patients with various cerebrovascular events.
  • To analyze factors influencing prognosis in this patient cohort.

Main Methods:

  • Multicentric, retrospective chart review across three academic tertiary care hospitals.
  • Identification of COVID-19 patients with cerebrovascular events requiring neuro-intensive care or neurosurgical consultation.
  • Analysis of patient demographics, clinical course, interventions, and outcomes.

Main Results:

  • 26 COVID-19 patients with cerebrovascular events were identified; 12 (46%) died.
  • Large-vessel occlusion (LVO) was the most common event (15 patients, 58%), with 53% mortality.
  • Mechanical thrombectomy in LVO patients had a 56% mortality rate; 27% of patients presented with intracranial hemorrhage.
  • Higher admission D-dimer levels and lower Glasgow Coma Scale (GCS) scores were associated with mortality.

Conclusions:

  • COVID-19 is associated with both ischemic and hemorrhagic cerebrovascular events.
  • Prognosis is poorer than anticipated, especially for LVO cases, even after mechanical thrombectomy.
  • Favorable neurological status on admission and lower D-dimer levels may indicate a better prognosis.
Abstract

Keywords:
COVID-19Cerebral venous sinus thrombosisIntracranial hemorrhageLarge-vessel occlusion (LVO)

More Related Videos

Optimized Management of Endovascular Treatment for Acute Ischemic Stroke09:21

Optimized Management of Endovascular Treatment for Acute Ischemic Stroke

Published on: January 18, 2018

12.2K
Comprehensive Endovascular and Open Surgical Management of Cerebral Arteriovenous Malformations14:58

Comprehensive Endovascular and Open Surgical Management of Cerebral Arteriovenous Malformations

Published on: October 20, 2017

9.9K

Related Concept Videos

Aneurysm II: Clinical Manifestations and Diagnostic Studies01:21

Aneurysm II: Clinical Manifestations and Diagnostic Studies

Thoracic, aortic arch and abdominal aneurysms are significant vascular conditions that can present with various clinical manifestations and lead to serious complications. Understanding these manifestations and the appropriate diagnostic studies is essential for effective management and treatment.Thoracic Aortic AneurysmsThoracic aortic aneurysms often remain asymptomatic until they reach a size that impinges on adjacent structures. They typically cause deep, diffuse chest pain that radiates to...
50
Venous Thrombosis III: Interprofessional Care01:29

Venous Thrombosis III: Interprofessional Care

Venous thrombosis requires effective prevention and treatment strategies to improve patient outcomes and reduce potential complications.Prevention StrategiesHealthcare providers must prioritize preventing venous thromboembolism (VTE) for all adult patients upon admission. Interventions depend on bleeding and thrombosis risk, medical history, current medications, diagnoses, planned procedures, and patient preferences. Patients on bed rest should change positions every two hours and, if not...
60
Venous Thrombosis II: Clinical Manifestations and Diagnostic Studies01:20

Venous Thrombosis II: Clinical Manifestations and Diagnostic Studies

The key difference between Superficial Vein Thrombosis (SVT) and Deep Vein Thrombosis (DVT) lies in their location and severity.Clinical ManifestationsSVT typically presents with localized pain, tenderness, and redness along the course of a superficial vein, often accompanied by a palpable, cord-like structure under the skin. This condition is usually less dangerous than DVT but can be uncomfortable and may lead to complications such as cellulitis or, rarely, a clot extension into the deep...
68
Aneurysm III: Interprofessional Care01:26

Aneurysm III: Interprofessional Care

Aneurysm management involves either conservative medical therapy or surgical intervention, depending on the size and symptoms of the aneurysm. Conservative management is generally reserved for smaller, asymptomatic aneurysms, while larger or symptomatic aneurysms often necessitate surgical repair.Conservative Medical TherapyFor small, asymptomatic aneurysms, particularly abdominal aortic aneurysms (AAA) less than 5.5 centimeters in diameter, conservative medical therapy is recommended. This...
54
Aneurysm IV: Nursing Management01:22

Aneurysm IV: Nursing Management

Vigilant monitoring for aneurysm rupture is essential for patients undergoing aortic surgery.Preoperative Nursing ManagementContinuously monitor the patient for manifestations of aneurysm rupture, such as pallor, weakness, tachycardia, hypotension, abdominal, back, groin, or periumbilical pain, changes in consciousness, and a pulsating abdominal mass. Regularly assess the patient's peripheral pulses.Instruct the patient to consume a clear liquid diet the day before surgery and administer...
42
Acute Coronary Syndrome III: Diagnostic Studies01:30

Acute Coronary Syndrome III: Diagnostic Studies

Diagnosing acute coronary syndrome or ACS begins with a thorough patient history. Notable symptoms include central, crushing chest pain radiating to the left arm, neck, jaw, or back, along with shortness of breath, sweating (diaphoresis), nausea, vomiting, dizziness, and palpitations.It is crucial to note any history of cardiac illnesses and assess risk factors, including age, gender, smoking, hypertension, diabetes, hyperlipidemia, and a sedentary lifestyle.During physical examination, vital...
46