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Selenium Vacancy Engineering Using Bi2Se3 Nanodots for Boosting Highly Efficient Photonic Hyperthermia.

Ding Wen1,2, Lile Dong1, Kai Li1

  • 1State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, China.

ACS Applied Materials & Interfaces
|October 11, 2021
PubMed
Summary

Researchers developed novel bismuth selenide nanomaterials (VSe-BS) for enhanced photothermal therapy. These VSe-BS nanoparticles show improved tumor targeting and high efficiency in destroying tumors using near-infrared light.

Keywords:
Bi2Se3NIR-II biowindowphotonic hyperthermiaselenium vacancy

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Area of Science:

  • Nanomedicine
  • Materials Science
  • Biomedical Engineering

Background:

  • Bismuth-based nanomaterials are promising for nanomedicine but face challenges like low tumor accumulation and poor photothermal conversion efficiency (PCE).
  • Defect engineering in nanomaterials offers a route to enhance their properties for biomedical applications.

Purpose of the Study:

  • To fabricate and evaluate bovine serum albumin and folic acid co-modified bismuth selenide (Bi2Se3) nanomedicine with selenium vacancies (VSe-BS) for near-infrared (NIR-II) light-triggered hyperthermia.
  • To investigate the impact of defect engineering on the conductivity, PCE, and photoacoustic imaging performance of Bi2Se3 nanomaterials.

Main Methods:

  • Fabrication of VSe-BS nanomedicine via co-modification with bovine serum albumin and folic acid.
  • Characterization of selenium vacancies using aberration-corrected scanning transmission electron microscopy.
  • Evaluation of photothermal conversion efficiency (PCE) under NIR-II light irradiation.
  • Assessment of photoacoustic imaging performance and tumor ablation efficacy in vivo.

Main Results:

  • Selenium vacancies were successfully introduced and observed on specific crystal planes of VSe-BS.
  • VSe-BS exhibited enhanced conductivity, leading to an outstanding PCE of 54.1% in the NIR-II biowindow.
  • The VSe-BS nanomedicine demonstrated desirable photoacoustic imaging performance and satisfactory tumor ablation outcomes triggered by NIR-II light.

Conclusions:

  • Defect engineering of bismuth selenide nanomaterials by introducing selenium vacancies significantly enhances their photothermal conversion efficiency and therapeutic efficacy.
  • VSe-BS nanomedicine offers a promising platform for NIR-II light-triggered photothermal therapy and photoacoustic imaging.
  • This study provides valuable insights for developing advanced defect-engineered bismuth-based nanomaterials for broader nanomedicine applications.