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Targeted optical fluorescence imaging: a meta-narrative review and future perspectives
H M Schouw1, L A Huisman1, Y F Janssen1
1Department of Surgery, University of Groningen, University Medical Centre Groningen, Groningen, The Netherlands.
Purpose:
The aim of this review is to give an overview of the current status of targeted optical fluorescence imaging in the field of oncology, cardiovascular, infectious and inflammatory diseases to further promote clinical translation.
Methods:
A meta-narrative approach was taken to systematically describe the relevant literature. Consecutively, each field was assigned a developmental stage regarding the clinical implementation of optical fluorescence imaging.
Results:
Optical fluorescence imaging is leaning towards clinical implementation in gastrointestinal and head and neck cancers, closely followed by pulmonary, neuro, breast and gynaecological oncology. In cardiovascular and infectious disease, optical imaging is in a less advanced/proof of concept stage.
Conclusion:
Targeted optical fluorescence imaging is rapidly evolving and expanding into the clinic, especially in the field of oncology. However, the imaging modality still has to overcome some major challenges before it can be part of the standard of care in the clinic, such as the provision of pivotal trial data. Intensive multidisciplinary (pre-)clinical joined forces are essential to overcome the delivery of such compelling phase III registration trial data and subsequent regulatory approval and reimbursement hurdles to advance clinical implementation of targeted optical fluorescence imaging as part of standard practice.
Insights
Targeted optical fluorescence imaging is advancing in oncology but requires more clinical trial data for widespread adoption. Overcoming regulatory and reimbursement hurdles is key to integrating this technology into standard medical practice.
Area of Science:
- Medical Imaging
- Oncology
- Cardiovascular Diseases
- Infectious Diseases
Background:
- Optical fluorescence imaging utilizes targeted agents to visualize biological processes.
- Its clinical translation is being explored across various medical fields.
Purpose of the Study:
- To review the current status of targeted optical fluorescence imaging.
- To assess its clinical implementation progress in oncology, cardiovascular, infectious, and inflammatory diseases.
Main Methods:
- A meta-narrative approach was employed for systematic literature review.
- Each disease field was evaluated for its developmental stage in clinical implementation.
Main Results:
- Optical fluorescence imaging shows promise for gastrointestinal, head and neck, pulmonary, neuro, breast, and gynecological cancers.
- Cardiovascular and infectious diseases are in earlier, proof-of-concept stages.
Conclusions:
- Targeted optical fluorescence imaging is rapidly evolving, particularly in oncology.
- Further clinical trials, regulatory approval, and reimbursement are necessary for standard practice integration.
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