Targeted optical fluorescence imaging: a meta-narrative review and future perspectives.

Area of Science:

• Medical Imaging
• Oncology
• Cardiovascular Diseases
• Infectious Diseases

Background:

• Optical fluorescence imaging utilizes targeted agents to visualize biological processes.
• Its clinical translation is being explored across various medical fields.

Purpose of the Study:

• To review the current status of targeted optical fluorescence imaging.
• To assess its clinical implementation progress in oncology, cardiovascular, infectious, and inflammatory diseases.

Main Methods:

• A meta-narrative approach was employed for systematic literature review.
• Each disease field was evaluated for its developmental stage in clinical implementation.

Main Results:

• Optical fluorescence imaging shows promise for gastrointestinal, head and neck, pulmonary, neuro, breast, and gynecological cancers.
• Cardiovascular and infectious diseases are in earlier, proof-of-concept stages.

Conclusions:

• Targeted optical fluorescence imaging is rapidly evolving, particularly in oncology.
• Further clinical trials, regulatory approval, and reimbursement are necessary for standard practice integration.