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The patient pathway for overactive bladder management: A quantitative analysis.

Auke J Seinen1, Rogier Elburg1, Lianne M Hollegien1

  • 1Department of Urology, Isala Clinics, Zwolle, The Netherlands.

Neurourology and Urodynamics
|October 11, 2021
PubMed
Summary
This summary is machine-generated.

Most overactive bladder patients need multiple treatments for symptom relief, often requiring over six months. Botulinum toxin A injections proved most effective, but side effects and poor response frequently halt treatment.

Keywords:
real-world datatreatment effectivenessurgency incontinence

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Area of Science:

  • Urology
  • Pharmacology
  • Patient pathways

Background:

  • Overactive bladder (OAB) significantly impacts quality of life.
  • Understanding patient treatment journeys is crucial for optimizing OAB management.

Purpose of the Study:

  • To investigate the treatment pathways for patients diagnosed with overactive bladder (OAB).
  • To analyze the sequence, duration, effectiveness, and reasons for discontinuation of OAB treatments.

Main Methods:

  • Retrospective cohort study of 120 female OAB patients.
  • Analysis of treatment steps, duration, effectiveness, and discontinuation reasons.
  • Evaluation of drug therapy, pelvic floor muscle therapy, botulinum toxin A, and nerve stimulation.

Main Results:

  • Patients required a median of 2 treatment steps over 28 weeks.
  • Initial treatments included antimuscarinics or mirabegron.
  • Botulinum toxin A injections showed the highest effectiveness (67%), followed by nerve stimulation (50%).
  • Insufficient response and side effects were primary reasons for discontinuation.

Conclusions:

  • OAB management often necessitates multiple treatment steps and significant time to achieve symptom relief.
  • Botulinum toxin A and nerve stimulation offer effective options for refractory OAB.
  • Managing patient and clinician expectations regarding treatment timelines and effectiveness is important.