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Pathomechanisms behind cognitive disorders following ruptured anterior communicating aneurysms: A diffusion tensor
Kévin Premat1, Carole Azuar2, Damien Galanaud1
1Sorbonne University, AP-HP, Pitié Salpêtrière - Charles Foix Hospital, Department of Neuroradiology, F75013, Paris, France.
Journal of Neuroradiology = Journal De Neuroradiologie
|October 11, 2021
Summary
Diffusion Tensor Imaging (DTI) reveals subtle white matter injuries in patients with anterior communicating artery aneurysms, even with normal MRI scans. These injuries correlate with cognitive deficits, particularly in frontal areas.
Area of Science:
- Neuroimaging
- Neurology
- Radiology
Background:
- Anterior communicating artery aneurysms frequently cause cognitive impairment.
- Cognitive deficits can occur despite normal conventional MRI findings.
- Diffusion Tensor Imaging (DTI) may elucidate underlying pathomechanisms.
Purpose of the Study:
- To compare DTI parameters between patients with normal-appearing MRI after aneurysm rupture and controls.
- To investigate the relationship between DTI findings and cognitive disorders.
Main Methods:
- A case-control study comparing volumetric and voxel-based DTI parameters.
- Included patients with normal morphological imaging (ACOM group) and a control population.
- Neuropsychological assessments were performed 6 months post-rupture.
Main Results:
- 75% of the ACOM group experienced cognitive domain deficits.
- Significant differences in global white matter DTI parameters (Fractional Anisotropy) were observed.
- Alterations were noted in frontal white matter tracts and the fornix.
Conclusions:
- Cognitive disorders post-aneurysm rupture are often underestimated.
- DTI detects diffuse neuronal injuries not visible on conventional MRI.
- Injuries are predominantly in frontal areas near the rupture site.
