Penetration of N-formimidoyl thienamycin into extravascular fluids in rabbits

The penetration of N-formimidoyl thienamycin into extravascular fluids was studied in rabbits. Two different models were used: subcutaneously implanted tissue chambers and fibrin clots. The antibiotic was given intramuscularly as a single dose of 10 mg/kg. The degree of penetration into these compartments was determined by comparing the area under the curve for the specific fluid with the area under the curve for plasma expressed in percent. The percentage of penetration of N-formimidoyl thienamycin into tissue chamber fluid (76.24%) was similar to that into fibrin clots (75.15%).