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The prevalence of Myocardial Infarction among Multiple Sclerosis Patients: a Systematic Review and Meta-analysis

Mohammad Javad Tavallaei1, Amir Hossein Tavallaei2, Narges Ebrahimi3

  • 1School of medicine, Iran university of medical sciences, Tehran, Iran.

Multiple Sclerosis and Related Disorders
|October 11, 2021
PubMed
Abstract

Insights

People with multiple sclerosis face a higher risk of myocardial infarction (MI), a serious heart condition. This review confirms this increased risk, highlighting the need for cardiovascular care in MS patient management.

Area of Science:

  • Neurology
  • Cardiology
  • Epidemiology

Background:

  • Multiple sclerosis (MS) is associated with increased mortality compared to the general population.
  • Cardiovascular diseases, particularly myocardial infarction (MI), may contribute to this higher mortality rate in people with MS (PwMS).

Purpose of the Study:

  • To systematically review and compare the prevalence of MI in PwMS versus the non-MS population.

Main Methods:

  • A systematic literature search was conducted across PubMed, Scopus, Embase, and Web of Science.
  • Studies were excluded if they focused solely on ischemic heart disease, autopsy data, pre-existing cardiovascular conditions, or MS diagnosed post-MI.
  • A random-effects model was used to determine the pooled prevalence of MI.

Main Results:

  • Nineteen studies involving 44 to 66,616 participants were included.
  • The overall prevalence of MI among PwMS was found to be 1.7%.
  • A pooled odds ratio of 1.41 indicated a significantly higher likelihood of MI in PwMS compared to the general population.

Conclusions:

  • This systematic review confirms an elevated risk of myocardial infarction in people with multiple sclerosis.
  • Cardiovascular health must be a key consideration in the comprehensive management of PwMS.
Keywords:
Multiple SclerosisMyocardial Infarctionmeta-analysisprevalencesystematic review

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