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WNT5B in cellular signaling pathways

Rachel S Perkins1, Sarocha Suthon1, Gustavo A Miranda-Carboni2

  • 1Department of Orthopaedic Surgery and Biomedical Engineering, University of Tennessee Health Science Center, Memphis, TN, USA.

Seminars in Cell & Developmental Biology
|October 12, 2021
PubMed

Insights

WNT5B, a Wnt signaling ligand, plays roles in development and disease. This review details its signal transduction, covering receptors, mediators, and transcription factors in both beta-catenin dependent and independent pathways.

Area of Science:

  • Molecular Biology
  • Developmental Biology
  • Cell Signaling

Background:

  • Wnt signaling pathway involvement in development and disease.
  • WNT5B is a key ligand in Wnt signaling.
  • Limited understanding of WNT5B's specific signaling mechanisms.

Purpose of the Study:

  • To review WNT5B's regulation of signal transduction.
  • To elucidate WNT5B's role in beta-catenin dependent and independent pathways.
  • To consolidate current knowledge on WNT5B signaling.

Main Methods:

  • Literature review of WNT5B research.
  • Analysis of WNT5B's interaction with receptors.
  • Examination of downstream mediators and transcription factors.

Main Results:

  • WNT5B regulates signal transduction from receptors to transcription factors.
  • WNT5B participates in beta-catenin dependent Wnt signaling.
  • WNT5B is involved in beta-catenin independent pathways, including Planar Cell Polarity and Wnt/Ca2+ signaling.

Conclusions:

  • WNT5B is a versatile signaling molecule with diverse roles.
  • Further research into WNT5B signaling mechanisms is warranted.
  • Understanding WNT5B is crucial for both normal development and disease states.
Keywords:
Beta-cateninCa(2+) signalingPlanar cell polarityWNT signalingWNT5B

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