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Related Concept Videos

Canonical Wnt Signaling Pathway02:54

Canonical Wnt Signaling Pathway

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The gene encoding the main signaling molecules of the Wnt signaling pathways (the Wnt proteins) was discovered almost four decades ago by Nüsslein-Volhard and Wieschaus. They identified and originally named the gene "wingless" (wg) after a phenotype discovered during their landmark genetic screen in Drosophila for body pattern defects. At around the same time, another researcher named Harold Varmus found that a murine tumor virus activates the mammalian wg homolog, Int-1, which...
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Non-Canonical Wnt Signaling Pathways01:41

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Wnt is a zygotic effect gene that is expressed during very early embryonic development. It regulates various processes in animals starting from early development through the adult stage, such as organogenesis in the embryo and maintenance of neuronal and blood stem cells. Wnt proteins can induce a wide variety of intracellular pathways depending upon the specific abilities of different Wnt ligands to form a complex with shared and cognate receptors in the presence of different co-receptors. The...
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TGF - β Signaling Pathway01:16

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The TGF-β signaling pathway regulates cell growth, differentiation, adhesion, motility, and development. TGF-β ligands that induce TGF-β signaling are synthesized in their latent form. Several proteases or cell surface receptors such as integrins act upon the latent form, releasing the active ligand. There are three types of mammalian TGF-βs: (TGF-β1, TGF-β2, and TGF-β3) that bind as homodimers or heterodimers to TGF-β receptors. The TGF-β receptors...
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Catenins01:23

Catenins

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Catenins are characterized by multiple binding domains and dynamic structures that allow them to function as linker proteins in cell junction complexes. All catenins, except α-catenin, contain a characteristic protein sequence called the armadillo repeat and are therefore also called armadillo proteins.
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Interactions Between Signaling Pathways01:19

Interactions Between Signaling Pathways

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Signaling cascades usually lack linearity. Multiple pathways interact and regulate one another, allowing cells to integrate and respond to diverse environmental stimuli.
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Diversity in Cell Signaling Responses01:22

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The physiological function of a cell and cellular communication are outcomes of a range of extrinsic signals, intracellular signaling pathways, and cellular responses. No two cell types express the same repertoire of signaling components. Receptors are highly selective for their cognate ligands, but once activated, they can alter multiple cellular processes such as DNA transcription, protein synthesis, and metabolic activity. 
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Modeling Paracrine Noncanonical Wnt Signaling In Vitro
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WNT5B in cellular signaling pathways.

Rachel S Perkins1, Sarocha Suthon1, Gustavo A Miranda-Carboni2

  • 1Department of Orthopaedic Surgery and Biomedical Engineering, University of Tennessee Health Science Center, Memphis, TN, USA.

Seminars in Cell & Developmental Biology
|October 12, 2021
PubMed
Summary
This summary is machine-generated.

WNT5B, a Wnt signaling ligand, plays roles in development and disease. This review details its signal transduction, covering receptors, mediators, and transcription factors in both beta-catenin dependent and independent pathways.

Keywords:
Beta-cateninCa(2+) signalingPlanar cell polarityWNT signalingWNT5B

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Area of Science:

  • Molecular Biology
  • Developmental Biology
  • Cell Signaling

Background:

  • Wnt signaling pathway involvement in development and disease.
  • WNT5B is a key ligand in Wnt signaling.
  • Limited understanding of WNT5B's specific signaling mechanisms.

Purpose of the Study:

  • To review WNT5B's regulation of signal transduction.
  • To elucidate WNT5B's role in beta-catenin dependent and independent pathways.
  • To consolidate current knowledge on WNT5B signaling.

Main Methods:

  • Literature review of WNT5B research.
  • Analysis of WNT5B's interaction with receptors.
  • Examination of downstream mediators and transcription factors.

Main Results:

  • WNT5B regulates signal transduction from receptors to transcription factors.
  • WNT5B participates in beta-catenin dependent Wnt signaling.
  • WNT5B is involved in beta-catenin independent pathways, including Planar Cell Polarity and Wnt/Ca2+ signaling.

Conclusions:

  • WNT5B is a versatile signaling molecule with diverse roles.
  • Further research into WNT5B signaling mechanisms is warranted.
  • Understanding WNT5B is crucial for both normal development and disease states.