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Tentative disk diffusion susceptibility interpretive criteria for pefloxacin.

P C Fuchs, A L Barry, R N Jones

Journal of Clinical Microbiology

|September 1, 1986

Summary

Standardized susceptibility testing for pefloxacin in clinical isolates is crucial. The study recommends a 5-microgram disk and proposes specific zone diameter breakpoints for classifying bacterial susceptibility.

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Area of Science:

Microbiology
Clinical Pharmacy
Infectious Diseases

Background:

Pefloxacin is a fluoroquinolone antibiotic used to treat bacterial infections.
Standardized susceptibility testing is essential for guiding effective antibiotic therapy.

Purpose of the Study:

To establish standardized susceptibility testing methods for pefloxacin.
To propose reliable breakpoints for interpreting pefloxacin susceptibility in clinical isolates.

Main Methods:

Standardized broth microdilution and disk diffusion susceptibility tests were performed.
585 clinical bacterial isolates were analyzed.

Main Results:

A 5-micrograms pefloxacin disk was found to be suitable for susceptibility testing.

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Proposed breakpoints: susceptible ≥ 19 mm (MIC ≤ 2.0 µg/ml), resistant ≤ 15 mm (MIC > 4.0 µg/ml), intermediate 16–18 mm.

Conclusions:

The study provides validated breakpoints for pefloxacin susceptibility testing.
These breakpoints will aid clinicians in selecting appropriate antibiotic treatments.