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Robust hemostatic bandages based on nanoclay electrospun membranes
Yan Cui1,2, Zongwang Huang1, Li Lei3
1Department of Inorganic Materials, School of Minerals Processing and Bioengineering, Central South University, 410083, Changsha, China.
Nature Communications
|October 12, 2021
Summary
New nanoclay hemostatic membranes offer rapid and effective bleeding control for emergencies. These safe and biocompatible bandages show promising results in preclinical and clinical settings.
Area of Science:
- Biomaterials Science
- Nanotechnology
- Emergency Medicine
Background:
- Acute hemorrhage poses a significant threat in military conflicts, accidents, and surgery.
- Rapid hemostasis is crucial for pre-hospital care to prevent fatalities from massive bleeding.
- Existing hemostatic materials often fail to meet ideal criteria: safety, efficacy, convenience, and cost-effectiveness.
Purpose of the Study:
- To develop a novel, rapid, and effective hemostatic material.
- To investigate the hemostatic performance and biocompatibility of nanoclay-based membranes.
- To evaluate the potential of these membranes as practical hemostats for pre-hospital use.
Main Methods:
- Incorporation of nanoclay particles into polyvinylpyrrolidone (PVP) electrospun fibers.
- Fabrication of nanoclay electrospun membranes (NEMs), specifically kaolinite-based (KEM1.5) with 60 wt% nanoclay.
- In vitro and in vivo testing of hemostatic performance and biocompatibility.
Main Results:
- The KEM1.5 membrane demonstrated superior and accelerated hemostatic performance compared to other NEMs and clay-based hemostats.
- Enhanced hemostatic efficacy attributed to abundant functional sites, a robust framework, and a hydrophilic surface.
- Positive biocompatibility results observed in both in vitro and in vivo evaluations.
Conclusions:
- Nanoclay electrospun membranes, particularly KEM1.5, represent a highly effective hemostatic material.
- The developed hemostatic bandages are a promising candidate for practical applications in managing massive bleeding.
- This innovation addresses the need for safe, efficient, and convenient hemostats in critical situations.
