Hypercoagulability in patients with indirect carotid cavernous fistulas
Trishal Jeeva Patel1, Kirill Zaslavsky1, Patrick Nicholson2
1Department of Ophthalmology and Visual Sciences, University of Toronto, Toronto, ON, Canada.
Eye (London, England)
|October 12, 2021
Summary
Sixty-four percent of patients with indirect carotid-cavernous fistulas (CCF) showed evidence of a hypercoagulable state (HS). This suggests hypercoagulability may contribute to CCF development and warrants further investigation.
Area of Science:
- Neurology
- Vascular Surgery
- Hematology
Background:
- Indirect carotid-cavernous fistulas (CCF) are complex vascular lesions.
- The role of hypercoagulable states (HS) in CCF pathogenesis is not fully understood.
Purpose of the Study:
- To evaluate the prevalence of hypercoagulable states in patients with indirect CCF.
- To identify potential risk factors and associations related to HS in this patient population.
Main Methods:
- A retrospective study of 22 patients diagnosed with indirect CCF between 2003 and 2019.
- Patients underwent a comprehensive medical questionnaire and extensive laboratory testing for thrombophilia markers.
- HS was defined by abnormal laboratory results or a history of thromboembolic events/conditions.
Main Results:
- 14 out of 22 patients (64%) exhibited evidence of HS.
- HS was identified through medical history, laboratory findings, or a combination of both.
- A significant portion of patients (36%) had current abnormal hypercoagulability markers.
Conclusions:
- A high prevalence of HS was observed in patients with indirect CCF.
- These findings suggest that hypercoagulability may be a contributing factor in the development of CCF.
- Comprehensive HS screening in CCF patients is recommended for improved management and prevention of thromboembolic events.
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