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Updated: Oct 17, 2025

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Visible-Light-Driven Multicomponent Cyclization by Trapping a 1,3-Vinylimine Ion Intermediate: A Direct Approach to
Xiao Geng1, Zhaoliang Xu1, Yiwen Cai1
1Advanced Research Institute and Department of Chemistry, Taizhou University, Taizhou, Zhejiang 318000, P. R. China.
Abstract:
Here we develop a novel visible-light-driven three-component cyclization by trapping an 1,3-vinylimine ion intermediate for the direct synthesis of pyrimido[1,2-b]indazole derivatives from bromodifluoroacetic acid derivatives, enaminones, and 3-aminoindazoles under mild conditions. Notably, the robust methodology provides a valuable opportunity for the introduction of aliphatic substituents and enables good compatibility of complex bioactive molecules. Furthermore, this is the first example of photoinduced multicomponent reaction by employing bromodifluoroacetic acid derivatives as a C1-synthon.
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