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Management of Diabetic Foot Ulcer with MA-ECM (Minimally Manipulated Autologous Extracellular Matrix) Using 3D
Rajesh Kesavan1,2, Changam Sheela Sasikumar3,4, V B Narayanamurthy5
1Department of Podiatric Surgery, NRA Wound Care Pvt Ltd, Hycare Super speciality Hospital, Chennai, Tamilnadu, India.
The International Journal of Lower Extremity Wounds
|October 12, 2021
Summary
Minimally manipulated extracellular matrix (MA-ECM) derived from 3D bioprinted adipose tissue significantly accelerated diabetic foot ulcer healing. This novel scaffold promoted complete wound closure and re-epithelialization within four weeks, offering a promising alternative to standard care.
Area of Science:
- Regenerative Medicine
- Biomaterials Engineering
- Diabetology
Background:
- Diabetic foot ulcers (DFU) cause significant morbidity, prolonged hospitalizations, and social limitations.
- Conventional treatments for DFU are often slow, costly, and lead to recurrent hospital visits.
- Autologous lipotransfer shows promise due to the regenerative properties of adipose tissue.
Purpose of the Study:
- To evaluate the efficacy of 3D bioprinted minimally manipulated extracellular matrix (MA-ECM) derived from autologous adipose tissue for treating diabetic foot ulcers.
- To compare the healing rates of DFU treated with MA-ECM scaffolds versus standard wound care.
Main Methods:
- A total of 40 patients with DFU were screened and randomized into two groups: a test group receiving MA-ECM scaffolds and a control group receiving standard wound care.
- MA-ECM scaffolds were customized and fabricated using a 3D bioprinter from the patient's own adipose tissue.
- Wound size reduction and epithelialization were assessed weekly for all participants.
Main Results:
- Patients in the test group (n=17) achieved complete wound closure with re-epithelialization in approximately 4 weeks.
- The control group (n=16) receiving standard wound care experienced delayed healing compared to the MA-ECM group.
- The MA-ECM scaffold demonstrated accelerated healing in diabetic foot ulcers.
Conclusions:
- 3D bioprinted MA-ECM scaffolds represent a personalized therapeutic approach for accelerating diabetic wound healing.
- This novel technique shows potential as an alternative treatment to prevent lower foot amputations in diabetic patients.
- MA-ECM derived from adipose tissue offers a promising regenerative strategy for complex wound management.
