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Ocular Involvement in the Histiocytoses: A Literature Review with an Illustrative Case Series
Jennifer Kim1, Laura R Steeples1,2, Nicholas P Jones3
1Manchester Royal Eye Hospital, Manchester University Hospitals NHS Foundation Trust, Manchester, UK.
Purpose:
To describe and illustrate recent reclassification and clinical descriptions of the histiocytoses, diagnosis and management, and effects on the eye and adnexae.
Patients And Methods:
Literature review with an illustrative case series of seven patients with histiocytosis and ophthalmic involvement from a single tertiary centre.
Results:
Skin lesions with signs including eyelid mass, orbital bone destruction, bizarre keratic precipitates, limbal or iris mass, haemorrhagic anterior uveitis, subretinal lesions of uncertain etiology, ischaemic retinopathy, optic neuropathy, and apparent steroid-resistant inflammations should be comprehensively investigated.
Conclusions:
Ophthalmic involvement in histiocytosis is rare. Clinical manifestations vary from limited single-organ disease to lethal systemic infiltration or malignancy. Radiology may identify lesions for biopsy. Histology with appropriate markers is essential. Oncology advice may be required.
