Related Experiment Video
Updated: Oct 17, 2025
12:40
A Modified Murine Heterotopic Heart Transplant Protocol Matching Contemporary Standards of Aseptic Technique, Anesthesia, and Analgesia
Published on: September 28, 2022
1.9K
Modified Technique for Retrograde Cerebral Perfusion during Hemiarch Aortic Replacement.
Nicholas T Kouchoukos1, Marc Haynes1, Sarah Hester1
1Division of Cardiovascular and Thoracic Surgery, Missouri Baptist Medical Center, BJC Healthcare, St. Louis, Missouri.
Aorta (Stamford, Conn.)
|October 12, 2021
Summary
Deep hypothermic circulatory arrest with retrograde cerebral perfusion offers safe and effective brain protection during hemiarch aortic replacement, reducing ischemia and clearing the arterial circulation.
Area of Science:
- Cardiovascular Surgery
- Neurosurgery
- Anesthesiology
Background:
- Optimal brain protection during aortic arch surgery remains debated.
- This study evaluates a technique using deep hypothermic circulatory arrest (DHCA) and retrograde cerebral perfusion (RCP).
Purpose of the Study:
- To assess the early outcomes of DHCA with RCP for brain protection in hemiarch aortic replacement.
Main Methods:
- A 15-year study of 520 patients undergoing hemiarch replacement.
- Utilized DHCA (mean 17.1°C, 19.3 min) with a brief RCP interval (mean 6.7 min).
Main Results:
- Low in-hospital/30-day mortality (1.2%) and stroke rates (1.4%).
- Transient neurologic dysfunction occurred in 3.7%; renal failure in 0.77%.
- Median hospital stay was 6 days.
Conclusions:
- DHCA with brief RCP is safe and effective for brain protection in hemiarch replacement.
- RCP shortens brain ischemia and aids in clearing arterial circulation.
