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Chronic toxicity study of cyclohexanone in rats and mice
Journal of the National Cancer Institute
|October 1, 1986
Summary
This study investigated cyclohexanone toxicity in rats and mice over two years. While higher doses affected weight and survival, particularly in female mice, evidence for cyclohexanone carcinogenicity was weak and marginal.
Area of Science:
- Toxicology
- Carcinogenesis
- Animal Studies
Background:
- Cyclohexanone is a widely used industrial chemical.
- Understanding its chronic toxicity and carcinogenic potential is crucial for risk assessment.
Purpose of the Study:
- To evaluate the chronic toxicity and carcinogenicity of cyclohexanone in F344 rats and (C57BL/6 X C3H)F1 mice.
- To determine dose-response relationships for any observed toxic or carcinogenic effects.
Main Methods:
- A 2-year chronic toxicity assay involving oral administration of cyclohexanone in drinking water.
- Utilized F344 rats and (C57BL/6 X C3H)F1 mice at various dose levels.
- Monitored survival, weight gain, and incidence of neoplasms.
Main Results:
- Weight gain was depressed at higher cyclohexanone doses in both species.
- Survival was reduced in female mice at the highest doses (25,000 ppm).
- Marginal increases in specific tumors (adrenal cortex adenomas in male rats, lymphomas-leukemias in female mice, hepatocellular adenomas/carcinomas in male mice) were observed, but evidence for carcinogenicity was weak.
Conclusions:
- Cyclohexanone exhibits toxicity at higher doses, affecting weight and survival.
- The evidence for cyclohexanone's carcinogenic activity in rodents is marginal and the effect is weak.
- Further research may be needed to fully elucidate potential long-term health risks.