Advances in Functional Imaging of Differentiated Thyroid Cancer

The present review provides a description of recent advances in the field of functional imaging that takes advantage of the functional characteristics of thyroid neoplastic cells (such as radioiodine uptake and FDG uptake) and theragnostic approach of differentiated thyroid cancer (DTC). Physical and biological characteristics of available radiopharmaceuticals and their use with state-of-the-art technologies for diagnosis, treatment, and follow-up of DTC patients are depicted. Radioactive iodine is used mostly with a therapeutic intent, while PET/CT with ¹⁸F-FDG emerges as a useful tool in the diagnostic management and complements the use of radioactive iodine. Beyond ¹⁸F-FDG PET/CT, other tracers including ¹²⁴I, ¹⁸F-TFB and ⁶⁸Ga-PSMA, and new methods such as PET/MR, might offer new opportunities in selecting patients with DTC for specific imaging modalities or treatments.