Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Cancer Stem Cells and Tumor Maintenance02:40

Cancer Stem Cells and Tumor Maintenance

5.1K
Early diagnosis and treatment can often cure cancer. However, even with treatment, residual cells called cancer stem cells (CSC) might remain, often causing tumor recurrence. These cancer stem cells possess the potential for self-renewal and multi-lineage differentiation and are often responsible for the therapeutic resistance displayed in most cancers.
Cancer stem cells are thought to originate from tissue-specific normal stem cells or progenitor cells. The normal stem cells usually reside in...
5.1K
Stem Cell Therapy for Tissue Regeneration01:21

Stem Cell Therapy for Tissue Regeneration

4.3K
Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
Types of Stem Cells used in Stem Cell Therapy
The two main cell...
4.3K
Distinctive Features of Adult Stem Cells vs Cancer Stem Cells01:18

Distinctive Features of Adult Stem Cells vs Cancer Stem Cells

3.8K
A stem cell is an unspecialized cell that can divide without limit as needed and can, under specific conditions, differentiate into specialized cells.
Adult stem cells
Adult stem cells are tissue-specific; hence, they divide to develop the tissue from which they originate. One type of adult stem cell is the epithelial stem cell, which gives rise to the keratinocytes in the multiple layers of epithelial cells in the epidermis of the skin. Adult bone marrow has three distinct types of stem cells:...
3.8K
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

8.0K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
8.0K
Mesenchymal Stem Cells01:19

Mesenchymal Stem Cells

5.1K
Mesenchymal stem cells (MSCs) are adult stem cells that can differentiate into most connective tissue cell types, except for hematopoietic cells, depending upon the source of MSCs. For example, bone-marrow-derived MSCs (BM-MSCs) can differentiate into osteocytes, hepatocytes, and pancreatic and neuronal cells. MSCs can be isolated from various sources such as bone marrow, placenta, adipose tissue, teeth, and Wharton’s jelly, a gelatinous substance in the umbilical cord. The ease of their...
5.1K
Tumor Immunotherapy01:27

Tumor Immunotherapy

741
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
741

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Surface plasmon resonance temperature sensor based on a photonic crystal fiber filled with silver nanowires.

Applied optics·2020
Same author

Absorption-Enhanced Ultra-Thin Solar Cells Based on Horizontally Aligned p-i-n Nanowire Arrays.

Nanomaterials (Basel, Switzerland)·2020
Same author

Risk factors of death from vascular events among cancer survivors: A SEER database analysis.

Medicina clinica·2020
Same author

Total bile acid to platelet ratio: A noninvasive index for predicting liver fibrosis in primary biliary cholangitis.

Medicine·2020
Same author

Corticosteroid treatment in severe COVID-19 pneumonia: two cases and literature review.

Clinical rheumatology·2020
Same author

<i>ZNF139</i>/<i>circZNF139</i> promotes cell proliferation, migration and invasion via activation of PI3K/AKT pathway in bladder cancer.

Aging·2020

Related Experiment Video

Updated: Oct 17, 2025

Studying Pancreatic Cancer Stem Cell Characteristics for Developing New Treatment Strategies
07:29

Studying Pancreatic Cancer Stem Cell Characteristics for Developing New Treatment Strategies

Published on: June 20, 2015

19.8K

Cancer Stem Cell for Tumor Therapy.

Binjie Huang1,2, Xin Yan1,2, Yumin Li1,2

  • 1Department of General Surgery, Second Hospital of Lanzhou University, Lanzhou 730030, China.

Cancers
|October 13, 2021
PubMed
Summary

Targeting cancer stem cells (CSCs) offers a promising strategy to inhibit tumor growth and recurrence. This review details CSC biology and explores various targeted therapies, including immunotherapy, for improved cancer treatment outcomes.

Keywords:
CSCsmetabolic phenotypemitotic division patterntargeted strategytherapeutic resistancetumor therapy

More Related Videos

Establishment of Cancer Stem Cell Cultures from Human Conventional Osteosarcoma
09:25

Establishment of Cancer Stem Cell Cultures from Human Conventional Osteosarcoma

Published on: October 14, 2016

19.3K
Isolation and Characterization of Tumor-initiating Cells from Sarcoma Patient-derived Xenografts
07:18

Isolation and Characterization of Tumor-initiating Cells from Sarcoma Patient-derived Xenografts

Published on: June 13, 2019

7.1K

Related Experiment Videos

Last Updated: Oct 17, 2025

Studying Pancreatic Cancer Stem Cell Characteristics for Developing New Treatment Strategies
07:29

Studying Pancreatic Cancer Stem Cell Characteristics for Developing New Treatment Strategies

Published on: June 20, 2015

19.8K
Establishment of Cancer Stem Cell Cultures from Human Conventional Osteosarcoma
09:25

Establishment of Cancer Stem Cell Cultures from Human Conventional Osteosarcoma

Published on: October 14, 2016

19.3K
Isolation and Characterization of Tumor-initiating Cells from Sarcoma Patient-derived Xenografts
07:18

Isolation and Characterization of Tumor-initiating Cells from Sarcoma Patient-derived Xenografts

Published on: June 13, 2019

7.1K

Area of Science:

  • Oncology
  • Cancer Stem Cell Biology
  • Therapeutic Strategies

Background:

  • Tumors present a significant health challenge, with conventional treatments like chemotherapy and radiotherapy often yielding unsatisfactory results.
  • Cancer stem cells (CSCs) are increasingly recognized for their pivotal roles in tumor initiation, progression, metastasis, and recurrence.
  • Targeted therapies offer enhanced specificity and efficiency compared to traditional cancer treatments.

Purpose of the Study:

  • To provide a comprehensive overview of the biological characteristics of cancer stem cells (CSCs).
  • To summarize and evaluate various strategies for targeting CSCs.
  • To highlight the potential of immunotherapy and combination therapies for anti-CSC treatments.

Main Methods:

  • Review of existing literature on cancer stem cell biology.
  • Analysis of CSC characteristics including mitotic patterns, metabolic phenotypes, and therapeutic resistance mechanisms.
  • Compilation of CSC-targeted strategies, encompassing surface markers, signaling pathways, niches, metabolic pathways, differentiation therapy, and immunotherapy.

Main Results:

  • CSCs exhibit distinct biological features, including specific mitotic patterns, metabolic phenotypes, and inherent therapeutic resistance.
  • A wide array of CSC-targeting strategies are available, including targeting surface markers, signaling pathways, niches, and metabolic vulnerabilities.
  • Immunotherapy, including tumor vaccines, CAR-T cells, oncolytic viruses, and immune checkpoint inhibitors, shows significant potential, especially in combination with other anti-CSC approaches.

Conclusions:

  • Targeting cancer stem cells is a viable approach to inhibit tumor progression and improve patient prognosis.
  • A diverse range of therapeutic strategies exist for targeting CSCs, offering multiple avenues for intervention.
  • Combination therapies, particularly those involving immunotherapy, hold great promise for overcoming CSC-mediated tumor resistance and enhancing treatment efficacy.