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Related Experiment Video

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Retinal Explant of the Adult Mouse Retina as an Ex Vivo Model for Studying Retinal Neurovascular Diseases

Retinal Explant of the Adult Mouse Retina as an Ex Vivo Model for Studying Retinal Neurovascular Diseases

Published on: December 9, 2022

Looking for In Vitro Models for Retinal Diseases.

Margherita Alfonsetti¹, Vanessa Castelli¹, Michele d'Angelo¹

¹Department of Life, Health and Environmental Sciences, University of L'Aquila, 67100 L'Aquila, Italy.

International Journal of Molecular Sciences

|October 13, 2021

Summary

Developing advanced in vitro models is crucial for studying retinal diseases. This review explores 2D and 3D models for understanding visual pathologies and aiding drug screening.

Keywords:

3D models cellular models in vitro organoids retinal degeneration

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Area of Science:

Ophthalmology and Vision Science
Cell Biology
Toxicology

Background:

Retinal pathologies are a leading cause of blindness globally.
The retina's complex layered structure is vital for vision.
In vitro models are essential for preclinical research and drug development.

Purpose of the Study:

To review common retinal diseases and their in vivo models.
To focus on alternative 2D and 3D in vitro models for retinal research.
To highlight models that replicate retinal cellular and matrix components.

Main Methods:

Literature review of retinal diseases and existing in vivo models.
Analysis of current 2D and 3D in vitro models for retinal research.
Identification of models that mimic retinal structure and disease insults.

Main Results:

2D models are suitable for drug screening and toxicology.
3D models better replicate physiological conditions for pathological studies.
Various in vitro models can simulate retinal layers and injury insults.

Conclusions:

In vitro models, both 2D and 3D, are vital for advancing retinal disease research.
These models facilitate the study of disease mechanisms and the development of new therapies.
Further development of in vitro models will improve preclinical testing and clinical translation.