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From Emollients to Biologicals: Targeting Atopic Dermatitis
Lorenzo Salvati1, Lorenzo Cosmi1, Francesco Annunziato1
1Department of Experimental and Clinical Medicine, University of Florence, 50134 Florence, Italy.
Abstract:
Atopic dermatitis (AD) is the most common chronic inflammatory skin disease and significantly impacts patients' lives, particularly in its severe forms. AD clinical presentation varies over the course of the disease, throughout different age groups, and across ethnicities. AD is characterized by a spectrum of clinical phenotypes as well as endotypes. Starting from the current description of AD pathogenesis, this review explores the rationale of approved AD therapies from emollients to biologicals and introduces novel promising drugs.
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