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A Quantitative Detection Method for MicroRNAs in the Kidney of an Ischemic Kidney Injury Mouse Model
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Syndecan-1 and Free Indoxyl Sulfate Levels Are Associated with miR-126 in Chronic Kidney Disease

Ophélie Fourdinier1, Griet Glorieux2, Benjamin Brigant3

  • 1Nephrology Dialysis and Transplantation Department, Amiens University Hospital, 80054 Amiens, France.

International Journal of Molecular Sciences
|October 13, 2021
PubMed

Insights

In chronic kidney disease (CKD), miR-126 levels correlate with endothelial dysfunction and uremic toxins. This finding offers new insights into CKD

Area of Science:

  • Nephrology
  • Cardiovascular Research
  • Molecular Biology

Background:

  • Chronic kidney disease (CKD) is a significant global health issue linked to high mortality.
  • Endothelial dysfunction and the accumulation of uremic toxins are key features of CKD.
  • Reduced miR-126 levels are observed in CKD patients, suggesting its role in disease pathology.

Purpose of the Study:

  • To investigate the relationship between miR-126 levels and markers of endothelial dysfunction in CKD patients.
  • To explore the association between miR-126 and key uremic toxins across all stages of CKD.
  • To elucidate the physiopathology of CKD by correlating miR-126 with specific biomarkers.

Main Methods:

  • Analysis of miR-126 levels in a large cohort of CKD patients.
  • Correlation studies using univariate and multivariate analyses.
  • Assessment of endothelial dysfunction markers and representative uremic toxins (e.g., indoxyl sulfate, p-cresyl glucuronide).

Main Results:

  • A significant correlation was found between estimated glomerular filtration rate (eGFR) and most evaluated endothelial dysfunction markers.
  • miR-126 was associated with all tested uremic toxins, unlike the control cel-miR-39.
  • Multivariate analysis confirmed the correlation between miR-126 and the endothelial dysfunction biomarker Syndecan-1, free indoxyl sulfate, and total p-cresyl glucuronide.

Conclusions:

  • miR-126 levels are significantly associated with endothelial dysfunction and uremic toxin accumulation in CKD.
  • These findings highlight the potential role of miR-126 in CKD pathophysiology.
  • Further research is warranted to evaluate the role of these correlated parameters in the reduced endothelial glycocalyx (eGC) observed in CKD.

Keywords:
biomarkerchronic kidney diseaseendothelium dysfunctionindoxyl sulfatemiR-126microRNAsyndecan-1uremic toxins

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