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Related Concept Videos

Treatment for Pulmonary Arterial Hypertension: Receptor Tyrosine Kinase Inhibitors and Calcium Channel Blockers01:26

Treatment for Pulmonary Arterial Hypertension: Receptor Tyrosine Kinase Inhibitors and Calcium Channel Blockers

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Receptor tyrosine kinase inhibitors (TKIs) and calcium channel blockers (CCBs) are two critical categories of drugs employed in the treatment of pulmonary artery hypertension (PAH). PAH is a disease that causes high blood pressure in the pulmonary arteries, resulting in chest pain, fatigue, and shortness of breath.
TKIs, such as imatinib (Gleevec), are particularly effective in tackling the growth and mitogenic factors that become upregulated in PAH patients. These factors contribute to the...
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Updated: Oct 17, 2025

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miR-29a-3p/THBS2 Axis Regulates PAH-Induced Cardiac Fibrosis.

Chih-Hsin Hsu1, I-Fan Liu2,3, Hsuan-Fu Kuo4,5,6,7

  • 1Department of Internal Medicine, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan 704, Taiwan.

International Journal of Molecular Sciences
|October 13, 2021
PubMed
Summary

MicroRNA-29a-3p (miR-29a-3p) shows anti-fibrotic effects in pulmonary artery hypertension (PAH) by targeting thrombospondin-2 (THBS2). Lower miR-29a-3p and higher THBS2 levels indicate PAH progression and may serve as prognostic markers.

Keywords:
THBS2cardiomyocytesfibrosismiR-29a-3ppulmonary arterial hypertension

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Area of Science:

  • Biomedical research
  • Cardiovascular pathology
  • Molecular biology

Background:

  • Pulmonary artery hypertension (PAH) is characterized by extracellular matrix (ECM) remodeling and cardiac fibrosis.
  • MicroRNA-29a-3p (miR-29a-3p) is known to regulate ECM in other fibrotic conditions, but its role in PAH-induced cardiac fibrosis is not well understood.
  • Thrombospondin-2 (THBS2) is an ECM protein implicated in fibrosis.

Purpose of the Study:

  • To investigate the role of miR-29a-3p in cardiac fibrosis progression in PAH.
  • To determine the relationship between miR-29a-3p and THBS2 expression in PAH.
  • To evaluate the diagnostic and prognostic value of miR-29a-3p and THBS2 in PAH.

Main Methods:

  • Assessed miR-29a-3p and THBS2 expression in cell culture, a monocrotaline-induced PAH mouse model, and human PAH patients.
  • Investigated the direct targeting of THBS2 by miR-29a-3p.
  • Correlated circulating levels of miR-29a-3p and THBS2 with PAH diagnostic parameters.

Main Results:

  • Circulating levels of miR-29a-3p were decreased, while THBS2 levels were increased in patients and mice with PAH.
  • miR-29a-3p directly targets THBS2, inhibiting its expression.
  • miR-29a-3p demonstrated a direct anti-fibrotic effect on PAH-induced cardiac fibrosis.
  • Circulating miR-29a-3p and THBS2 levels correlated with PAH diagnostic parameters, indicating prognostic value.

Conclusions:

  • miR-29a-3p acts as a direct regulator of THBS2 in PAH-induced cardiac fibrosis.
  • miR-29a-3p exhibits anti-fibrotic properties relevant to PAH.
  • Circulating miR-29a-3p and THBS2 hold potential as diagnostic and prognostic biomarkers for PAH, with miR-29a-3p showing therapeutic promise.