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Updated: Oct 17, 2025

In Vivo Nanovector Delivery of a Heart-specific MicroRNA-sponge
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In Vivo Nanovector Delivery of a Heart-specific MicroRNA-sponge

Published on: June 15, 2018

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MicroRNAs and Calcium Signaling in Heart Disease

Jae-Ho Park1, Changwon Kho2

  • 1Division of Metabolism and Nutrition, Korea Food Research Institute, Iksan 55365, Korea.

International Journal of Molecular Sciences
|October 13, 2021
PubMed

Insights

Calcium (Ca2+) signaling is vital for heart function. This review explores how calcium-related microRNAs (miRNAs) impact heart diseases like hypertrophy and heart failure, offering potential therapeutic targets.

Area of Science:

  • Cardiovascular Biology
  • Molecular Cardiology
  • Gene Regulation

Background:

  • Calcium (Ca2+) signaling is essential for cardiac muscle contraction, electrical activity, and cell growth.
  • Dysregulation of Ca2+ handling proteins is a hallmark of heart disease.
  • MicroRNAs (miRNAs) are key regulators of gene expression, influencing cardiac Ca2+ cycling.

Purpose of the Study:

  • To review the role of cardiac Ca2+ signaling in pathological conditions.
  • To summarize the involvement of Ca2+-related miRNAs in heart diseases.
  • To discuss the therapeutic potential of miRNAs targeting Ca2+ handling.

Main Methods:

  • Literature review of studies on cardiac Ca2+ signaling.
  • Analysis of research on miRNAs in cardiac hypertrophy, heart failure, myocardial infarction, and atrial fibrillation.
  • Synthesis of findings on miRNA-mediated regulation of Ca2+ handling.

Main Results:

  • Impaired Ca2+ handling is central to various heart diseases.
  • Specific miRNAs are implicated in the pathophysiology of cardiac hypertrophy, heart failure, myocardial infarction, and atrial fibrillation.
  • Ca2+-related miRNAs represent promising biomarkers and therapeutic targets.

Conclusions:

  • Cardiac Ca2+ signaling is critically regulated by miRNAs.
  • Understanding miRNA-Ca2+ interactions is crucial for diagnosing and treating heart diseases.
  • Targeting Ca2+-related miRNAs offers a novel therapeutic strategy for cardiovascular conditions.

Keywords:
atrial fibrillationcalcium signalingcardiac hypertrophyheart failuremicroRNAmyocardial infarction

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