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Application of I TASSER, trRosetta, UCSF Chimera, HADDOCK server, and HEX loria for De Novo and In Silico Design of Proteins
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Inositols: From Established Knowledge to Novel Approaches
Simona Dinicola1, Vittorio Unfer1, Fabio Facchinetti2
1Systems Biology Group Lab, 00161 Rome, Italy.
International Journal of Molecular Sciences
|October 13, 2021
Summary
Myo-inositol and D-chiro-inositol are natural compounds that improve metabolic and reproductive health. Research shows they regulate sex hormones and can be used to treat conditions like PCOS and infertility.
Area of Science:
- Endocrinology
- Metabolic Health
- Reproductive Biology
Background:
- Myo-inositol (myo-Ins) and D-chiro-inositol (D-chiro-Ins) are naturally occurring compounds with significant roles in biological pathways.
- Their involvement in endocrine signal transduction has led to their use in treating gynecological and endocrinological diseases.
- They are well-tolerated alternatives to traditional insulin sensitizers for metabolic and reproductive disorders like PCOS, GDM, and male infertility.
Purpose of the Study:
- To review established evidence and recent research on inositols, focusing on D-chiro-inositol's role in steroidogenesis.
- To explore the mechanisms by which inositols influence sex hormone production.
- To discuss the therapeutic potential of inositol supplementation for metabolic and reproductive health.
Main Methods:
- Literature review of existing studies on myo-inositol and D-chiro-inositol.
- Analysis of research on inositol's impact on endocrine signaling and steroidogenesis.
- Examination of clinical data regarding inositol supplementation for various health conditions.
Main Results:
- D-chiro-inositol mediates insulin-induced testosterone biosynthesis in ovarian thecal cells.
- D-chiro-inositol directly influences estrogen synthesis by modulating aromatase enzyme expression.
- Specific myo-Ins to D-chiro-Ins ratios are crucial for ovarian function; altered ratios are linked to hormonal imbalances and conditions like PCOS.
Conclusions:
- Inositol supplementation can be a valuable therapeutic strategy for metabolic and reproductive disorders.
- Targeting the myo-Ins to D-chiro-Ins ratio offers potential for personalized treatment approaches.
- Further research is needed to fully elucidate inositol mechanisms and explore novel therapeutic applications.
Keywords:
D-chiro-InositolFSHGDMPCOSaromataseepimerasemyo-Inositolneural tube defectssteroidogenesistestosteroneMore Related Videos
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