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Detecting Diabetic Retinal Neuropathy Using Fundus Perimetry.

Takayuki Baba1

  • 1Department of Ophthalmology and Visual Science, Chiba University Graduate School of Medicine, Inohana 1-8-1, Chuo-ku, Chiba 260-8670, Japan.

International Journal of Molecular Sciences
|October 13, 2021
PubMed
Summary

Fundus perimetry offers a precise way to measure retinal sensitivity, detecting early vision loss in diabetic retinopathy before structural changes occur. This technique is crucial for monitoring disease progression and evaluating treatments.

Keywords:
diabetic maculopathyfundus perimetrymesopicoptical coherence tomographyretinal sensitivityscotopic

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Area of Science:

  • Ophthalmology
  • Retinal Imaging
  • Diabetic Retinopathy Research

Background:

  • Retinal sensitivity measurement is advancing with new technologies.
  • Fundus perimetry, particularly the MP-3 model, offers enhanced accuracy and capabilities.
  • Neuronal damage in diabetic retinopathy can precede visible vascular or morphological changes.

Purpose of the Study:

  • To review the importance of measuring retinal sensitivity for early detection of visual dysfunction in diabetic retinopathy.
  • To highlight the utility of fundus perimetry in assessing early-stage diabetic retinopathy.
  • To present retinal sensitivity as a valuable outcome measure in clinical trials for diabetic retinopathy treatments.

Main Methods:

  • Utilizes fundus perimetry, a point-to-point retinal light sense evaluation technique.
  • Employs the MP-3 fundus perimeter with advanced eye tracking and high background illumination.
  • Reviews recent investigations on neuronal damage and retinal function loss in diabetic retinopathy.

Main Results:

  • Fundus perimetry provides a detailed assessment of retinal sensitivity, distinct from visual acuity.
  • High background illumination allows for accurate mesopic retinal sensitivity measurements.
  • Evidence suggests retinal functional loss occurs before morphological changes in diabetic retinopathy.

Conclusions:

  • Measuring retinal sensitivity with fundus perimetry is vital for early diabetic retinopathy evaluation.
  • Retinal sensitivity serves as a promising outcome measure for clinical trials in diabetic retinopathy.
  • Fundus perimetry should be considered by diabetes researchers and ophthalmologists for comprehensive patient care.