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Updated: Oct 17, 2025

Analyses of Proteinuria, Renal Infiltration of Leukocytes, and Renal Deposition of Proteins in Lupus-prone MRL/lpr Mice
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Analyses of Proteinuria, Renal Infiltration of Leukocytes, and Renal Deposition of Proteins in Lupus-prone MRL/lpr Mice

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MicroRNAs in Lupus Nephritis-Role in Disease Pathogenesis and Clinical Applications

Benjamin Y F So1, Desmond Y H Yap1, Tak Mao Chan1

  • 1Division of Nephrology, Department of Medicine, Queen Mary Hospital, The University of Hong Kong, Hong Kong.

International Journal of Molecular Sciences
|October 13, 2021
PubMed

Insights

MicroRNAs (miRs) are key epigenetic regulators implicated in lupus nephritis (LN) pathogenesis. Further research is needed to explore their clinical utility in diagnosing and treating LN.

Area of Science:

  • Epigenetics
  • Molecular Biology
  • Nephrology

Background:

  • MicroRNAs (miRs) are small non-coding RNAs regulating gene expression epigenetically.
  • Their role in lupus nephritis (LN) pathogenesis is complex and increasingly recognized.
  • Altered miRs are detected in blood, urine, and kidney tissues of LN models and patients.

Purpose of the Study:

  • To summarize the current understanding of miRs in lupus nephritis.
  • To highlight the contribution of miRs to immune dysregulation and renal pathology in LN.
  • To discuss the potential and limitations of miRs in clinical applications for LN.

Main Methods:

  • Review of existing literature on miRs and lupus nephritis.
  • Analysis of miR expression patterns in LN models and patients.
  • Examination of miR functions in immune cells and renal cells.

Main Results:

  • miRs modulate immune cells and inflammatory pathways, contributing to LN pathogenesis.
  • Dysregulated miRs in renal cells and exosomes promote renal cell proliferation, inflammation, and fibrosis.
  • miRs show potential for clinical applications in LN diagnosis, monitoring, and treatment.

Conclusions:

  • miRs play a significant role in the complex pathogenesis of lupus nephritis.
  • Further investigation is crucial to address limitations and safety concerns for clinical miR utility in LN.
  • miRs may offer future diagnostic, prognostic, and therapeutic strategies for LN patients.
Keywords:
clinical applicationsepigeneticslupus nephritismicroRNApathogenesis

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