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Understanding the Renal Fibrotic Process in Leptospirosis
Luan Gavião Prado1,2, Angela Silva Barbosa1
1Laboratório de Bacteriologia, Instituto Butantan, Avenida Vital Brasil, 1500, São Paulo 05503-900, Brazil.
International Journal of Molecular Sciences
|October 13, 2021
Summary
Leptospirosis causes chronic kidney disease and fibrosis. This review explores cellular communication pathways in renal fibrosis and its link to chronic kidney disease (CKD) and chronic kidney disease of unknown etiology (CKDu).
Area of Science:
- Infectious Diseases
- Nephrology
- Cellular Biology
Background:
- Leptospirosis, caused by *Leptospira*, is a neglected infectious disease.
- Acute leptospirosis is understood, but chronic manifestations like renal disease and fibrosis are overlooked.
- Mechanisms of chronic *Leptospira* infection and renal fibrosis remain poorly understood.
Purpose of the Study:
- To review recent findings on cellular communication in leptospirosis-induced renal fibrosis.
- To explore the relationship between leptospirosis-associated renal fibrosis and chronic kidney disease (CKD/CKDu).
Main Methods:
- Literature review of recent findings.
- Analysis of cellular communication pathways.
- Examination of the link between leptospirosis and CKD/CKDu.
Main Results:
- Recent studies reveal key cellular communication pathways involved in renal fibrotic processes.
- Evidence suggests a connection between *Leptospira* infection and the development of renal fibrosis.
- The review highlights the potential role of leptospirosis in CKD/CKDu.
Conclusions:
- Understanding cellular communication is crucial for elucidating mechanisms of leptospirosis-induced renal fibrosis.
- Further research is needed to clarify the link between leptospirosis and CKD/CKDu.
- This review provides insights into the chronic aspects of leptospirosis and kidney disease.
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