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Skin Barrier Dysregulation in Psoriasis
Andreas Orsmond1,2, Lara Bereza-Malcolm1,2, Tom Lynch2
1Sutton Arthritis Research Laboratory, Faculty of Medicine and Health, Institute of Bone and Joint Research, Kolling Institute, University of Sydney at Royal North Shore Hospital, St Leonards, NSW 2065, Australia.
International Journal of Molecular Sciences
|October 13, 2021
Summary
This review explores the skin barrier
Area of Science:
- Dermatology and immunology, focusing on skin barrier function.
Background:
- The skin barrier, comprising physical and immune elements, is crucial for homeostasis.
- Dysregulation of the skin barrier can lead to diseases like psoriasis.
- Psoriasis involves disrupted barrier function, aberrant keratinocyte activity, and inflammation.
Purpose of the Study:
- To review recent discoveries in psoriasis pathogenesis.
- To highlight the roles of keratinocytes, immune cells, and genetic/environmental factors.
- To discuss how these insights can advance psoriasis treatments.
Main Methods:
- This is a review article, summarizing existing research.
- It synthesizes findings on skin barrier components and their interactions.
- It analyzes the contribution of cellular and etiological factors in psoriasis.
Main Results:
- Recent discoveries shed light on the complex interplay of factors in psoriasis.
- Understanding keratinocyte and immune cell contributions is key.
- Genetic and environmental factors significantly influence disease development.
Conclusions:
- Advances in understanding psoriasis pathogenesis offer new therapeutic avenues.
- Targeting barrier dysfunction and inflammation holds promise for future treatments.
- A comprehensive approach considering multiple factors is essential for effective psoriasis management.
Keywords:
environmental factorsgenetic aberrationimmune cellskeratinocytepsoriasisskin barriertreatmentMore Related Videos
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