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Updated: Oct 17, 2025

Development of an Antigen-driven Colitis Model to Study Presentation of Antigens by Antigen Presenting Cells to T Cells
Published on: September 18, 2016
Host-Viral Interactions in the Pathogenesis of Ulcerative Colitis
Torunn Bruland1,2, Ann Elisabet Østvik1,2, Arne Kristian Sandvik1,2,3
1Department of Clinical and Molecular Medicine, Norwegian University of Science and Technology, 7491 Trondheim, Norway.
This review explores how virus-induced innate immune responses contribute to ulcerative colitis inflammation. It highlights the dual role of viruses in potentially causing or protecting against this inflammatory bowel disease.
Area of Science:
- Immunology
- Gastroenterology
- Virology
Background:
- Ulcerative colitis involves recurring colonic inflammation.
- Viral infections activate innate immunity, releasing cytokines and causing inflammation.
- Intestinal viruses were previously considered neutral or harmful.
Purpose of the Study:
- To review virus-induced innate immune responses in ulcerative colitis.
- To discuss the complex role of viruses in gut inflammation.
Main Methods:
- Literature review of studies on viruses and ulcerative colitis.
- Analysis of innate immune pathways activated by viral infections.
- Examination of host-virus interactions in the gut.
Main Results:
- Persisting viruses may act as commensals, offering protection.
- Dysregulated immune responses to viruses can lead to pathogenic inflammation.
- Innate immune activation is central to virus-host interactions in colitis.
Conclusions:
- Virus-induced immune responses significantly impact ulcerative colitis pathogenesis.
- Understanding these responses is crucial for developing new therapeutic strategies.
- The role of viruses in inflammatory bowel disease requires further investigation.
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