Ambient Ozone, PM₁ and Female Lung Cancer Incidence in 436 Chinese Counties

Ozone air pollution has been increasingly severe and has become another major air pollutant in Chinese cities, while PM₁ is more harmful to human health than coarser PMs. However, nationwide studies estimating the effects of ozone and PM₁ are quite limited in China. This study aims to assess the spatial associations between ozone (and PM₁) and the incidence rate of female lung cancer in 436 Chinese cancer registries (counties/districts). The effects of ozone and PM₁ were estimated, respectively, using statistical models controlling for time, location and socioeconomic covariates. Then, three sensitivity analyses including the adjustments of smoking covariates and co-pollutant (SO₂) and the estimates of ozone, PM1 and SO₂ effects in the same model, were conducted to test the robustness of the effects of the two air pollutants. Further still, we investigated the modifying role of urban-rural division on the effects of ozone and PM₁. According to the results, a 10 μg/m³ increase in ozone and PM₁ was associated with a 4.57% (95% CI: 4.32%, 16.16%) and 4.89% (95% CI: 4.37%, 17.56%) increase in the incidence rate of female lung cancer relative to its mean, respectively. Such ozone and PM₁ effects were still significant in three sensitivity analyses. Regarding the modifying role of urban-rural division, the effect of PM₁ was greater by 2.98% (95% CI: 1.01%, 4.96%) in urban than in rural areas when PM1 changed by 10 μg/m³. However, there was no modification effect of urban-rural division for ozone. In conclusion, there were positive associations between ozone (and PM₁) and the incidence rate of female lung cancer in China. Urban-rural division may modify the effect of PM₁ on the incidence rate of female lung cancer, which is seldom reported. Continuous and further prevention and control measures should be developed to alleviate the situation of the two air pollutants.