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Related Concept Videos

Ankle Joint01:10

Ankle Joint

2.1K
The ankle is formed by the talocrural joint (crural = leg). It consists of the articulations between the talus bone of the foot and the distal ends of the tibia and fibula of the leg. The superior aspect of the talus bone is square-shaped and has three areas of articulation. The top of the talus articulates with the inferior tibia. This is the portion of the ankle joint that carries the body weight between the leg and foot. The sides of the talus are firmly held in position by the articulations...
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Genome-wide Association Studies-GWAS01:11

Genome-wide Association Studies-GWAS

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Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...
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Updated: Oct 17, 2025

Treatment of Ankle Osteoarthritis with Total Ankle Replacement Through a Lateral Transfibular Approach
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Ankle Osteoarthritis Aetiology.

Mario Herrera-Pérez1,2, David González-Martín1,2, Mercedes Vallejo-Márquez3

  • 1Foot and Ankle Unit, Orthopedic Surgery and Traumatology Service, Hospital Universitario de Canarias, Carretera de la Cuesta s/n, 38320 Santa Cruz de Tenerife, Spain.

Journal of Clinical Medicine
|October 13, 2021
PubMed
Summary

Ankle osteoarthritis, often stemming from prior trauma, impacts younger, active individuals. Both mechanical ankle joint issues and inflammation contribute to cartilage damage and disease development.

Keywords:
ankle cartilageankle fracturesankle osteoarthritisetiology

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Area of Science:

  • Orthopedics
  • Rheumatology
  • Sports Medicine

Background:

  • Ankle osteoarthritis affects 1% of the population, frequently secondary to trauma (over 75% of cases).
  • Unlike hip or knee osteoarthritis, it disproportionately affects a younger, active demographic, leading to significant socio-occupational consequences.
  • Key mechanical factors like incongruity, instability, malalignment, and impacts contribute to localized cartilage stress.

Purpose of the Study:

  • To elucidate the multifactorial etiology of ankle osteoarthritis.
  • To highlight the distinct characteristics and triggers of ankle osteoarthritis compared to other forms of osteoarthritis.
  • To emphasize the roles of both mechanical stress and inflammatory processes in disease pathogenesis.

Main Methods:

  • Review of existing literature on ankle osteoarthritis.
  • Analysis of biomechanical factors implicated in cartilage degeneration.
  • Examination of the role of inflammatory mediators post-fracture.

Main Results:

  • Ankle osteoarthritis is predominantly post-traumatic.
  • Mechanical ankle joint abnormalities are strongly linked to osteoarthritis development.
  • Pro-inflammatory mediators released during fracture initiate chondrocyte death, a key step in osteoarthritis progression.

Conclusions:

  • Ankle osteoarthritis pathogenesis involves a complex interplay of mechanical joint factors and inflammatory responses.
  • Early recognition of mechanical instability and inflammatory cascades is crucial for managing ankle osteoarthritis.
  • Further research into the inflammatory pathways could reveal novel therapeutic targets for ankle osteoarthritis.