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Systemic and Local Drug Delivery for Treating Diseases of the Central Nervous System in Rodent Models
Published on: August 16, 2010
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Controlled Drug Delivery Systems: Current Status and Future Directions.
Shivakalyani Adepu1, Seeram Ramakrishna1
1Center for Nanofibers and Nanotechnology, National University of Singapore (NUS), 21 Lower Kent Ridge Rd, Singapore 119077, Singapore.
Molecules (Basel, Switzerland)
|October 13, 2021
Summary
Controlled drug delivery systems enhance therapeutic efficacy by overcoming limitations of conventional methods. This review explores advancements from nano-scale to intelligent systems for precise drug release.
Area of Science:
- Pharmaceutical Sciences
- Biomaterials Science
- Pharmacology
Background:
- Conventional drug delivery systems (tablets, capsules, etc.) exhibit poor bioavailability and fluctuating plasma drug levels.
- Inefficient drug delivery can compromise therapeutic outcomes and patient safety.
- Controlled drug delivery aims to optimize drug release kinetics and target specificity.
Purpose of the Study:
- To provide a comprehensive overview of drug delivery systems, emphasizing controlled release.
- To discuss the evolution of drug delivery from conventional to advanced nano- and intelligent systems.
- To highlight recent advancements, challenges, and future directions in the field.
Main Methods:
- Review of existing literature on drug delivery systems.
- Analysis of pharmacokinetic principles relevant to drug delivery.
- Discussion of design considerations, classifications, and applications of controlled drug delivery systems.
- Exploration of nano-drug delivery, targeted delivery, and smart drug delivery using stimuli-responsive biomaterials.
Main Results:
- Conventional systems have significant limitations in bioavailability and controlled release.
- Controlled drug delivery systems offer improved therapeutic efficacy and safety through precise drug release.
- Recent advancements include nano-scale, targeted, and intelligent drug delivery systems utilizing advanced biomaterials.
Conclusions:
- Controlled drug delivery is crucial for maximizing therapeutic efficacy and minimizing side effects.
- The field has evolved significantly, with nano- and intelligent systems showing great promise.
- Addressing current challenges is essential for the future development of advanced drug delivery technologies.
Keywords:
controlled release dosage formsintelligent biomaterialsnano-drug deliverypharmacokineticssmart and stimuli-responsive deliveryMore Related Videos
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