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Autophagic Activation and Decrease of Plasma Membrane Cholesterol Contribute to Anticancer Activities in Non-Small

Jui-Ling Hsu1,2, Wohn-Jenn Leu1, Nan-Shan Zhong3

  • 1School of Pharmacy, National Taiwan University, No. 33, Linsen S. Rd., Zhongzheng Dist., Taipei 100, Taiwan.

Molecules (Basel, Switzerland)
|October 13, 2021
PubMed
Summary

Para-toluenesulfonamide shows promise as an anti-cancer drug for non-small cell lung cancer (NSCLC). It works by disrupting cell membrane cholesterol and activating autophagy, leading to cancer cell death.

Keywords:
Akt/mTOR/p70S6K pathwayautophagynon-small cell lung cancerpara-toluenesulfonamideplasma membrane cholesterol

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