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Related Concept Videos

Pulmonary Tuberculosis V01:28

Pulmonary Tuberculosis V

268
Medical management of tuberculosis (TB) patients involves a comprehensive approach that includes diagnosis, treatment, and monitoring. The specific strategies can vary depending on the type of tuberculosis (latent or active), the patient's overall health status, and other considerations.
Latent tuberculosis infection occurs when TB bacteria are present in a person's body, but are not causing illness or symptoms. It is not contagious, and preventive treatment is crucial to avoid the...
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Pulmonary Tuberculosis IV01:26

Pulmonary Tuberculosis IV

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Tuberculosis, more commonly referred to as TB, is an infectious disease stemming from Mycobacterium tuberculosis. While it primarily impacts the lungs, TB can also affect other body areas. Given its severity and global impact, timely and accurate diagnosis is crucial for controlling its spread and improving patient outcomes.
Several diagnostic approaches are used to detect TB. The conventional method is the Tuberculin Skin Test (TST), also known as the Mantoux test. However, this method has...
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Bioavailability Study Design: Healthy Subjects Versus Patients01:15

Bioavailability Study Design: Healthy Subjects Versus Patients

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Bioavailability studies are essential for evaluating a drug's therapeutic efficacy and understanding its absorption patterns under various physiological conditions. Conducting such studies on target patient populations provides more relevant data by simulating real-world disease states. However, practical challenges often necessitate the use of young, healthy adult volunteers as study subjects.Patients may exhibit altered drug absorption patterns due to the effects of the disease itself,...
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Pulmonary Tuberculosis I01:29

Pulmonary Tuberculosis I

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Tuberculosis, often called TB, is a contagious illness primarily caused by Mycobacterium tuberculosis. It mainly affects the lung parenchyma but can also impact other body parts.
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
418
Pulmonary Tuberculosis II01:28

Pulmonary Tuberculosis II

655
Tuberculosis, or TB, is a bacterial infectious disease caused by Mycobacterium tuberculosis. While its primary impact is on the lungs, leading to pulmonary tuberculosis, it can also affect various other organs, a condition referred to as extrapulmonary tuberculosis.
Here is a detailed explanation of its pathophysiology:
Transmission: The process begins when a person inhales droplet nuclei containing M. tuberculosis. These are typically released into the air when an individual with pulmonary or...
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Pulmonary Tuberculosis III01:31

Pulmonary Tuberculosis III

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Tuberculosis (TB) is a contagious infection primarily affecting the lung parenchyma but which can also affect other body parts. TB can be classified based on disease development, presentation, and the affected anatomical site.
The first classification is based on the development of the disease, and it includes the following categories:
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Related Experiment Video

Updated: Oct 17, 2025

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Tuberculosis-Learning the Impact of Nutrition (TB LION): protocol for an interventional study to decrease TB risk in

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Undernutrition and parasitic infections in India increase tuberculosis (TB) risk. Nutritional supplementation and parasite treatment may improve immune responses to Mycobacterium tuberculosis (Mtb) infection.

Keywords:
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Area of Science:

  • Immunology
  • Infectious Diseases
  • Public Health

Background:

  • Tuberculosis (TB) remains a significant global health challenge, particularly in TB-endemic countries like India.
  • Undernutrition and parasitic infections are prevalent comorbidities in these regions, potentially influencing TB susceptibility and progression.
  • The interplay between these conditions and immune responses to Mycobacterium tuberculosis (Mtb) requires further investigation.

Purpose of the Study:

  • To investigate the impact of undernutrition and parasitic infections on immune responses to Mtb infection.
  • To evaluate the efficacy of nutritional supplementation and parasite treatment in modulating these immune responses.
  • To identify immune signatures associated with TB risk and progression.

Main Methods:

  • A 5-year prospective clinical trial involving 760 household contacts (HHCs) of active TB patients in India.
  • Enrollment of 120 QFT-Plus positive HHCs aged ≥18 years into four groups: undernourished, parasitic infection, both, or controls.
  • Assessment of immune responses via flow cytometry and whole blood transcriptomics, alongside nutritional and parasitological evaluations (PCR, microscopy).

Main Results:

  • This section is to be filled after the study is completed and data is analyzed.

Conclusions:

  • This research aims to determine if undernutrition and parasitic infections are linked to TB risk gene signatures.
  • The study will elucidate whether interventions like nutritional supplementation and parasite treatment can enhance immune responses against Mtb.
  • Findings may contribute to reducing the overall burden of TB by identifying key factors influencing disease progression.