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Updated: Oct 17, 2025
Confocal Imaging of Double-Stranded RNA and Pattern Recognition Receptors in Negative-Sense RNA Virus Infection
Published on: January 26, 2019
ADAR1 entraps sinister cellular dsRNAs, thresholding antiviral responses
Liam P Keegan1, Dragana Vukić1, Mary A O'Connell1
1CEITEC Masaryk University, Kamenice 735/5, A35, Brno, CZ 62500, Czech Republic.
Abstract:
ADAR1 edits adenosines to inosines in cellular double-stranded (ds)RNA, thereby preventing aberrant activation of antiviral dsRNA sensors, as well as interferon (IFN) induction in Aicardi-Goutières syndrome (AGS) encephalopathy. Recently, Nakahama et al., Tang et al., Maurano et al., and de Reuver et al. demonstrated that Adar1 Zα domain-mutant mice show aberrant MDA5 and PKR activation, developing encephalopathies; short Z-RNA patches within cellular dsRNA are unexpectedly crucial in causing aberrant antiviral responses.
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