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Association Of -308G/A, -238G/A TNF-α Polymorphisms with Multiple Myeloma Risk and Survival: A Systematic Review and
Christina M Alymatiri1, Georgia T Gkegka1, Maria Gavriatopoulou1
1Department of Clinical Therapeutics, School of Medicine, National and Kapodistrian University of Athens, Athens, Greece.
Clinical Lymphoma, Myeloma & Leukemia
|October 13, 2021
Summary
This study found no link between tumor necrosis factor alpha (TNF-α) gene polymorphisms (-308G/A and -238G/A) and multiple myeloma (MM) risk or survival in Caucasian and East Asian populations.
Area of Science:
- Immunogenetics
- Oncology
- Molecular Epidemiology
Background:
- Tumor necrosis factor alpha (TNF-α) is a pro-inflammatory cytokine implicated in various diseases, including cancer.
- Specific TNF-α gene polymorphisms (-308G/A and -238G/A) are located in a highly variable region and have been investigated for disease associations.
- Conflicting conclusions exist regarding the role of these TNF-α polymorphisms in multiple myeloma (MM) risk.
Purpose of the Study:
- To conduct a systematic review and meta-analysis.
- To investigate the association between TNF-α polymorphisms (-308G/A and -238G/A) and multiple myeloma (MM) risk.
- To evaluate the impact of these polymorphisms on MM patient survival.
Main Methods:
- Systematic literature search of the PubMed database up to June 18, 2020.
- Quantitative synthesis using random-effects models (Der Simonian and Laird).
- Separate analyses by ethnicity and evaluation of Hardy-Weinberg equilibrium.
Main Results:
- Eighteen studies with 2934 cases and 4291 controls were included for risk analysis.
- Five studies with 557 cases were included for survival analysis.
- No significant association was found between the studied TNF-α polymorphisms and MM susceptibility or survival in any genetic model for Caucasians or East Asians.
Conclusions:
- This meta-analysis did not find evidence supporting a role for TNF-α -308G/A and -238G/A polymorphisms in multiple myeloma risk.
- The studied TNF-α polymorphisms do not appear to influence the survival outcomes of multiple myeloma patients.
- Further research may be needed to explore other genetic or environmental factors in MM pathogenesis.
