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Outcomes and complications of peripartum cardiomyopathy: protocol for a systematic review and meta-analysis

Julian Hoevelmann1,2, Elani Muller3, Ameer Hohlfeld4,5

  • 1Cape Heart Institute, Faculty of Health Sciences, University of Cape Town, Cape Town, Western Cape, South Africa julian.hovelmann@uct.ac.za.

BMJ Open
|October 13, 2021
PubMed

Insights

This systematic review protocol outlines a plan to analyze peripartum cardiomyopathy (PPCM) complications and outcomes. It aims to provide a comprehensive summary of maternal morbidity and mortality associated with PPCM.

Area of Science:

  • Cardiology
  • Obstetrics
  • Public Health

Background:

  • Peripartum cardiomyopathy (PPCM) is a significant cause of maternal morbidity and mortality globally.
  • PPCM is associated with severe complications, particularly in the early disease stages, including heart failure, arrhythmias, and thromboembolism.

Purpose of the Study:

  • To conduct a systematic review and meta-analysis to summarize available data on complications and outcomes in women with PPCM.
  • To report the burden of complications around diagnosis and 6- or 12-month outcomes for PPCM patients.

Main Methods:

  • A comprehensive literature search will be conducted across major databases (PubMed/MEDLINE, Web of Science, Scopus, EBSCO Host) for studies published from 2000 to June 2021.
  • Inclusion criteria encompass cohort studies, cross-sectional studies, and control arms of RCTs reporting PPCM complications and outcomes.
  • Risk of bias assessment and statistical heterogeneity testing (I², χ²) will be employed to ensure data quality and reliability.

Main Results:

  • This section will present pooled analyses of complications and outcomes from multiple centers, regions, and continents.
  • The study will quantify the incidence of various complications and their impact on maternal health.
  • Six-month and 12-month outcomes for women diagnosed with PPCM will be detailed.

Conclusions:

  • This systematic review and meta-analysis will enhance understanding of PPCM-related complications and outcomes.
  • The findings will inform clinical practice and guide management strategies for PPCM.
  • A global perspective on PPCM burden will be provided, aiding in improved maternal healthcare worldwide.
Abstract

Keywords:
adult cardiologycardiomyopathyheart failure

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