Anatomy of the Eyeball
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Updated: Oct 17, 2025

Assessing Pupil-linked Changes in Locus Coeruleus-mediated Arousal Elicited by Trigeminal Stimulation
Published on: November 26, 2019
Elisa Castaldi1,2, Antonella Pomè2, Guido Marco Cicchini3
1Department of Translational Research and New technologies in Medicine and Surgery, University of Pisa, Pisa, Italy.
Perceived numerosity, the sense of how many items are in a set, influences the automatic pupillary light reflex. This suggests numerosity is a fundamental visual feature processed even without conscious attention.
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