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Detection of MicroRNA Expression in the Kidneys of Immunoglobulin A Nephropathic Mice

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Published on: July 8, 2020

The mucosal immune system and IgA nephropathy.

Loreto Gesualdo¹, Vincenzo Di Leo², Rosanna Coppo³

¹Nephrology, Dialysis and Transplantation Unit, Department of Emergency and Organ Transplantation, University of Bari Aldo Moro, Bari, Italy. loreto.gesualdo@uniba.it.

Seminars in Immunopathology

|October 13, 2021

Summary

Immunoglobulin A nephropathy (IgAN) pathogenesis involves mucosal immunity, particularly mucosa-associated lymphoid tissue (MALT). Therapies targeting gut microbes and mucosal responses may offer new treatment avenues for IgAN.

Keywords:

Diet Gut-kidney axis IgA nephropathy Microbiota Mucosal immunity Tonsil-kidney axis

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Area of Science:

Nephrology
Immunology
Gastroenterology

Background:

The exact cause of immunoglobulin A nephropathy (IgAN) remains unclear.
Emerging research highlights the critical involvement of mucosal immunity in IgAN pathogenesis.

Purpose of the Study:

This review examines the role of mucosa-associated lymphoid tissue (MALT) in IgAN development.
It explores the interplay between microbiota, genetics, food antigens, infections, and mucosal immunity.

Main Methods:

Literature review focusing on mucosal immunity in IgAN.
Analysis of the relationship between environmental factors and immune responses.

Main Results:

Mucosa-associated lymphoid tissue (MALT) plays a central role in initiating IgAN.
Interactions between gut microbiota, genetic predispositions, dietary antigens, and infections influence mucosal immune responses.

Conclusions:

Understanding the mucosal immune system's role is crucial for IgAN pathogenesis.
Targeting microbial factors and mucosal hyperresponsiveness presents potential therapeutic strategies for IgAN patients.