PCOS and Depression: Common Links and Potential Targets
Jagruti V Kolhe1, Abu Sufiyan Chhipa1, Shital Butani2
1Department of Pharmacology, Institute of Pharmacy, Nirma University, Ahmedabad, 382481, Gujarat, India.
Reproductive Sciences (Thousand Oaks, Calif.)
|October 13, 2021
Summary
Polycystic ovary syndrome (PCOS) is linked to increased depression, potentially due to shared inflammatory pathways and hormonal imbalances. Understanding these connections may lead to better treatments for women with PCOS and depression.
Area of Science:
- Endocrinology
- Psychiatry
- Reproductive Health
Background:
- Polycystic ovary syndrome (PCOS) is a common endocrine disorder affecting reproductive-aged females.
- PCOS presents with diverse symptoms like irregular periods, obesity, acne, and infertility.
- Increased depression incidence and reduced quality of life (QOL) are noted in women with PCOS.
Purpose of the Study:
- To explore shared links and common associations between depression and PCOS.
- To investigate potential inflammatory relationships and hormonal overlaps between PCOS and depression.
- To identify common biochemical markers that may link PCOS and depression.
Main Methods:
- Review of existing literature on PCOS, depression, and their overlapping symptoms.
- Analysis of studies investigating inflammatory markers in both conditions.
- Examination of hormonal and neurotransmitter levels (cortisol, androgen, vitamin D, MAO, IGF-1) in relation to PCOS and depression.
Main Results:
- PCOS and depression share overlapping clinical symptoms and low self-esteem.
- Both conditions exhibit pro-inflammatory states with elevated inflammatory markers.
- Potential links exist through hormonal imbalances and neurotransmitter dysregulation.
Conclusions:
- Inflammation may be a key shared pathway linking PCOS and depression.
- Hormonal factors like cortisol, androgens, and neurotransmitter imbalances contribute to the comorbidity.
- Identifying these shared mechanisms can guide novel therapeutic strategies to improve QOL for affected women.
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