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High alanine aminotransaminase associated with daptomycin use in a premature infant

Suzan Suhail Asfour1, Fahad Aljobair2, Adli Abdelrahim3

  • 1Clinical Pharmacy Department, Pharmacy Department, King Saud Medical City, Riyadh, Saudi Arabia.

Journal of Mother and Child
|October 13, 2021
PubMed

Insights

Daptomycin, an antibiotic for gram-positive infections, may cause liver damage in premature infants. A case study revealed elevated liver enzymes and coagulation issues shortly after daptomycin administration in a neonate.

Area of Science:

  • Pharmacology
  • Neonatal Medicine
  • Infectious Diseases

Background:

  • Daptomycin is a lipopeptide antibiotic effective against gram-positive bacteria.
  • Its use in premature infants is established for various infections.

Purpose of the Study:

  • To report a case of potential hepatotoxicity in a premature infant receiving daptomycin.
  • To highlight a previously unrecognized adverse drug effect.

Main Methods:

  • Case report of a premature infant treated with daptomycin.
  • Monitoring of liver function tests (alanine aminotransaminase) and coagulation parameters (prothrombin time, international normalised ratio).

Main Results:

  • The infant developed elevated alanine aminotransaminase, prolonged prothrombin time, and increased international normalised ratio.
  • These changes occurred rapidly following daptomycin administration.

Conclusions:

  • Daptomycin may be associated with hepatotoxicity and coagulopathy in premature infants.
  • Close monitoring for liver function and coagulation is recommended in this population.

Keywords:
coagulase-negative staphylococcidaptomycindisseminated intravascular coagulationhepatotoxicityinfant

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