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Elevated platelet distribution width and red cell distribution width are associated with autoimmune liver diseases
Muge Ustaoglu1, Gulali Aktas2, Ufuk Avcioglu1
1Department of Gastroenterology, Faculty of Medicine, Ondokuz Mayis University, Samsun.
European Journal of Gastroenterology & Hepatology
|October 13, 2021
Summary
Red blood cell distribution width (RDW) and platelet distribution width (PDW) can help identify autoimmune liver disease (ALD). Elevated RDW and PDW levels were significantly higher in ALD patients, showing diagnostic potential.
Area of Science:
- Hepatology
- Clinical Chemistry
- Immunology
Background:
- Red blood cell distribution width (RDW) and platelet distribution width (PDW) are emerging inflammatory markers.
- Autoimmune liver disease (ALD) is a chronic inflammatory condition affecting the liver.
Purpose of the Study:
- To investigate the association between RDW and PDW with ALD.
- To evaluate the diagnostic utility of RDW and PDW in ALD.
Main Methods:
- Retrospective analysis of 126 ALD patients and 69 healthy controls.
- Comparison of laboratory parameters including RDW, PDW, AST, ALT, and CRP.
- Assessment of sensitivity and specificity of RDW and PDW for ALD detection.
Main Results:
- ALD patients exhibited significantly higher levels of RDW, PDW, AST, ALT, and CRP compared to controls.
- RDW showed significant correlations with AST and CRP.
- PDW demonstrated significant correlations with AST, ALT, and CRP.
- RDW and PDW achieved considerable sensitivity and specificity in diagnosing ALD.
Conclusions:
- RDW and PDW are valuable biomarkers for identifying ALD.
- These parameters, particularly PDW, offer significant diagnostic potential for ALD.
