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The TRIM proteins in cancer: from expression to emerging regulatory mechanisms

A Mohammadi1, M S Pour Abbasi2, S Khorrami3

  • 1Department of Genetics Islamic, Azad University of Marand, Marand, Iran.

Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico
|October 13, 2021
PubMed

Insights

Dysregulation of ubiquitin-mediated destruction is implicated in leukemia and carcinoma. Tripartite motif (TRIM) proteins, crucial E3 ubiquitin ligases, regulate cell processes and influence cancer development.

Area of Science:

  • Oncology
  • Molecular Biology
  • Biochemistry

Background:

  • Ubiquitin-mediated protein destruction is crucial for regulating tumor suppressors and oncogenes.
  • Dysregulation of these pathways is linked to the development of leukemia and carcinoma.
  • The tripartite motif (TRIM) protein family comprises significant E3 ubiquitin ligases involved in carcinogenesis.

Purpose of the Study:

  • To review the mechanisms by which TRIM proteins regulate prevalent human malignancies.
  • To summarize the role of TRIM proteins in cancer etiology and progression.

Main Methods:

  • Literature review of clinical evidence and molecular mechanisms.
  • Analysis of TRIM protein functions in various cancer types.

Main Results:

  • TRIM proteins are involved in essential biological processes like cell growth, differentiation, and apoptosis.
  • Alterations in TRIM proteins can significantly impact cell proliferation and transcriptional regulation.
  • TRIM proteins play diverse roles in major cancers including lung, prostate, colorectal, liver, breast, brain cancer, and leukemia.

Conclusions:

  • TRIM proteins are vital regulators in the development and progression of various cancers.
  • Understanding TRIM protein mechanisms offers potential therapeutic targets for malignancies.
Keywords:
CancerCancer therapyTRIMTumor progression

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