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Infectious Diseases and Their Occurrence

Infectious Diseases and Their Occurrence

Infectious diseases appear in populations through various transmission patterns, influenced by pathogen characteristics, population immunity, environmental conditions, and social behavior. Understanding these patterns is essential for effective public health surveillance and intervention. These categories—sporadic, outbreak, epidemic, pandemic, and endemic—help frame the nature and scope of disease events.Sporadic diseases occur irregularly and infrequently, without a predictable temporal or...

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Related Experiment Video

Updated: Jun 8, 2026

Organoids as Model for Infectious Diseases: Culture of Human and Murine Stomach Organoids and Microinjection of Helicobacter Pylori

Organoids as Model for Infectious Diseases: Culture of Human and Murine Stomach Organoids and Microinjection of Helicobacter Pylori

Published on: November 12, 2015

Organoid Models for Infectious Disease.

Sarah E Blutt^1,2, Mary K Estes^1,3

¹Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, Texas 77030, USA;

Annual Review of Medicine

|October 13, 2021

Summary

This summary is machine-generated.

New organoid models offer advanced tools for studying infectious diseases, aiding in the development of novel treatments and preventive strategies for better human health outcomes.

Keywords:

infection organoid pathogenesis stem cell therapies

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Area of Science:

Infectious disease research
Stem cell biology
Organoid technology

Background:

Infectious diseases pose significant individual and societal health challenges.
Developing effective preventive and therapeutic treatments requires advanced research models.
Current models often lack the complexity to fully replicate human host-pathogen interactions.

Purpose of the Study:

To highlight the utility of organoid models in understanding infectious diseases.
To explore how organoids can advance the study of host-microbe interactions.
To discuss the potential of organoid cultures in improving human health.

Main Methods:

Utilizing pluripotent and tissue stem cell-derived organoids.
Studying host-microbe interactions in respiratory, gastrointestinal, and neuronal systems.
Investigating the impact of increased culture complexity (stroma, interorgan communication, microbiome).

Main Results:

Organoid models successfully recapitulate key characteristics of in vivo infectious diseases.
Organoids provide novel insights into human host-microbe interactions across various organ systems.
Enhanced organoid complexity promises more accurate disease modeling.

Conclusions:

Organoid cultures are powerful tools for investigating infectious disease pathogenesis and host responses.
These models are crucial for developing new preventive and therapeutic strategies.
Organoid technology holds significant potential to improve human health outcomes related to infectious diseases.